Synthesis of new 5-or 7-substituted 3-nitroimidazo[1,2-a ]pyridine derivatives using S N Ar and Palladium-catalyzed reactions to explore antiparasitic structure-activity relationships Paoli-Lombardo, R. Primas, N. /Bourgeade-Delmas, Sandra Sournia-Saquet, A. Castera-Ducros, C. Jacque, I. Verhaeghe, P. Rathelot, P. Vanelle, P. nitroaromatic compounds imidazo[1,2-a ]pyridines kinetoplastids nucleophilic aromatic substitution palladium-catalyzed cross-coupling reactions microwave irradiation Figure 1 Structures of metronidazole and antikinetoplastid nitroheterocyclic drug compounds. To study the antikinetoplastid structure-activity relationships in a 3-nitroimidazo[1,2- a ]pyridine series, we explored the substitution of positions 5 and 7 of the scaffold, developing nucleophilic aromatic substitution reactions and palladium-catalyzed Suzuki-Miyaura, Sonogashira, and Buchwald-Hartwig cross-coupling reactions that had never been reported at these positions in this series. In four steps from 2-amino(bromo)pyridines, 33 original compounds were obtained, allowing a better definition of the antiparasitic pharmacophore. 2024 text https://www.documentation.ird.fr/hor/fdi:010091877 fdi:010091877 Paoli-Lombardo R., Primas N., Bourgeade-Delmas Sandra, Sournia-Saquet A., Castera-Ducros C., Jacque I., Verhaeghe P., Rathelot P., Vanelle P.. Synthesis of new 5-or 7-substituted 3-nitroimidazo[1,2-a ]pyridine derivatives using S N Ar and Palladium-catalyzed reactions to explore antiparasitic structure-activity relationships. 2024, 56 (08), 1297-1308 EN