@article{fdi:010091877,
  title = {{S}ynthesis of new 5-or 7-substituted 3-nitroimidazo[1,2-a ]pyridine derivatives using {S} {N} {A}r and {P}alladium-catalyzed reactions to explore antiparasitic structure-activity relationships},
  author = {{P}aoli-{L}ombardo, {R}. and {P}rimas, {N}. and {B}ourgeade-{D}elmas, {S}andra and {S}ournia-{S}aquet, {A}. and {C}astera-{D}ucros, {C}. and {J}acque, {I}. and {V}erhaeghe, {P}. and {R}athelot, {P}. and {V}anelle, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}igure 1 {S}tructures of metronidazole and antikinetoplastid nitroheterocyclic drug compounds. {T}o study the antikinetoplastid structure-activity relationships in a 3-nitroimidazo[1,2- a ]pyridine series, we explored the substitution of positions 5 and 7 of the scaffold, developing nucleophilic aromatic substitution reactions and palladium-catalyzed {S}uzuki-{M}iyaura, {S}onogashira, and {B}uchwald-{H}artwig cross-coupling reactions that had never been reported at these positions in this series. {I}n four steps from 2-amino(bromo)pyridines, 33 original compounds were obtained, allowing a better definition of the antiparasitic pharmacophore.},
  keywords = {nitroaromatic compounds ; imidazo[1,2-a ]pyridines ; kinetoplastids ; nucleophilic aromatic substitution ; palladium-catalyzed cross-coupling ; reactions ; microwave irradiation},
  booktitle = {},
  journal = {{S}ynthesis},
  volume = {56},
  numero = {08},
  pages = {1297--1308},
  ISSN = {0039-7881},
  year = {2024},
  DOI = {10.1055/a-2232-8113},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091877},
}