Aghokeng Fobang Avelin auteur aut IRD Ngo-Giang-Huong Nicole auteur aut IRD Huynh T. H. K. auteur aut IRD Dagnra A. Y. auteur aut IRD Toni T. D. auteur aut IRD Maiga A. auteur aut IRD Dramane K. auteur aut IRD Eymard-Duvernay Sabrina auteur aut IRD Chaix M. L. auteur aut IRD Calvez V. auteur aut IRD Descamps D. auteur aut IRD text journalArticle eng text/pdf born digital access Objectives Integrase strand transfer inhibitors (INSTIs) have been recently recommended as the preferred first-line option for antiretroviral treatment initiators in low- and middle-income countries (LMICs) in response to the growing circulation of resistant HIV to non-nucleoside reverse transcriptase inhibitors (NNRTIs). In this study, we estimated the frequency of pretreatment drug resistance (PDR) to INSTIs in West Africa and Southeast Asia. Materials and methods Using samples collected from 2015 to 2016, and previously used to assessed PI, NRTI and NNRTI resistance, we generated HIV integrase sequences and identified relevant INSTI PDR mutations using the Stanford and ANRS algorithms.Results We generated 353 integrase sequences. INSTI PDR frequency was low, 1.1% (4/353) overall, ranging from 0% to 6.3% according to country. However, frequency of PDR to any drug class was very high, 17.9% (95% CI: 13.9%-22.3%), and mostly associated with a high level of NNRTI PDR, 9.7%, and a moderate level of NRTI PDR, 5.3%.Conclusions Our results support the recent introduction of INSTIs in LMICs to improve treatment outcome in these settings, but also stress the need for effective actions to prevent uncontrolled emergence of drug resistance to this drug class. specialized AFRIQUE DE L'OUEST ASIE DU SUD EST 050 052 79 5 1164-1168 2024 0305-7453 https://www.documentation.ird.fr/hor/fdi:010091603 10.1093/jac/dkae087 0305-7453 [F B010091603] https://www.documentation.ird.fr/hor/fdi:010091603 https://www.documentation.ird.fr/intranet/publi/2024-08/010091603.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2024-05-22 2025-11-06 fdi:010091603 fre