@article{fdi:010091589,
  title = {{S}chistosoma haematobium and {S}chistosoma bovis first generation hybrids undergo gene expressions changes consistent with species compatibility and heterosis},
  author = {{M}athieu-{B}{\'e}gn{\'e}, {E}. and {K}incaid-{S}mith, {J}ulien and {C}haparro, {C}. and {A}llienne, {J}.{F}. and {R}ey, {O}. and {B}oissier, {J}. and {T}oulza, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}hen two species hybridize, the two parental genomes are brought together and some alleles might interact for the first time. {T}o date, the extent of the transcriptomic changes in first hybrid generations, along with their functional outcome constitute an important knowledge gap, especially in parasite species. {H}ere we explored the molecular and functional outcomes of hybridization in first-generation hybrids between the blood fluke parasites {S}chistosoma haematobium and {S}. bovis. {T}hrough a transcriptomic approach, we measured gene expression in both parental species and hybrids. {W}e described and quantified expression profiles encountered in hybrids along with the main biological processes impacted. {U}p to 7,100 genes fell into a particular hybrid expression profile (intermediate between the parental expression levels, over-expressed, under-expressed, or expressed like one of the parental lines). {M}ost of these genes were different depending on the direction of the parental cross ({S}. bovis mother and {S}. haematobium father or the reverse) and depending on the sex. {F}or a given sex and cross direction, the vast majority of genes were hence unassigned to a hybrid expression profile: either they were differentially expressed genes but not typical of any hybrid expression profiles or they were not differentially expressed neither between hybrids and parental lines nor between parental lines. {T}he most prevalent profile of gene expression in hybrids was the intermediate one (24% of investigated genes). {T}hese results suggest that transcriptomic compatibility between {S}. haematobium and {S}. bovis remains quite high. {W}e also found support for an over-dominance model (over- and under-expressed genes in hybrids compared to parental lines) potentially associated with heterosis. {I}n females in particular, processes such as reproductive processes, metabolism and cell interactions as well as signaling pathways were indeed affected. {O}ur study hence provides new insight on the biology of {S}chistosoma hybrids with evidences supporting compatibility and heterosis.},
  keywords = {{SENEGAL} ; {BENIN} ; {MALI} ; {NIGER} ; {CAMEROUN} ; {COTE} {D}'{IVOIRE} ; {NIGERIA} ; {FRANCE} ; {CORSE}},
  booktitle = {},
  journal = {{PLOS} {N}eglected {T}ropical {D}iseases},
  volume = {18},
  numero = {7},
  pages = {e0012267 [22 ]},
  ISSN = {1935-2735},
  year = {2024},
  DOI = {10.1371/journal.pntd.0012267},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091589},
}