@article{fdi:010091397,
  title = {{P}erformance of visual inspection, partial genotyping, and their combination for the triage of women living with {HIV} who are screen positive for human papillomavirus : {R}esults from the {AIMA}-{CC} {ANRS} 12375 multicentric screening study},
  author = {{B}eaudrap, {P}ierre de and {K}abore, {F}. {N}. and {S}etha, {L}. and {T}egbe, {J}. and {D}oukoure, {B}. and {S}otheara, {M}. and {S}egeral, {O}. and {A}un, {K}. and {M}essou, {E}. and {B}itolog, {P}. and {S}othea, {K}. and {V}assilakos, {P}. and {P}oda, {A}. and {P}oda, {E}. {K}. and {J}aquet, {A}. and {S}ome, {A}. and {P}etignat, {P}. and {C}lifford, {G}. and {H}oro, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {WHO} recommends the use of human papillomavirus ({HPV}) testing for primary cervical cancer ({CC}) screening because of its high sensitivity. {H}owever, triage is desirable to correctly identify {HPV}+ women who have high-grade lesions ({CIN}2+) and require treatment. {T}he {ANRS}-12375 study was conducted in {C} & ocirc;te d'{I}voire, {B}urkina {F}aso and {C}ambodia to assess the performance, feasibility and benefits of different triage options for detecting {CIN}2+ lesions: partial ({HPV}16 and {HPV}16/18/45) and extended genotyping, visual inspection ({VIA}) alone and {VIA} combined with partial genotyping. {VIA} was performed by gynecologists. {T}he sensitivity, specificity, and diagnostic likelihood ratio ({DLR}) of each triage option for detecting {CIN}2+ lesions with histology as a reference standard were calculated. {O}f the 2253 women living with {HIV} ({WLHIV}) included, 932 (41%) were {HPV}+. {A} {CIN}2+ lesion was identified in 105 (13%) of the 777 participants with histopathology results. {T}he sensitivity of {VIA} as a triage test for {CIN}2+ patients was 89%, while that for extended genotyping was 89%, that for {HPV}16/18/45 partial genotyping was 51%, and that for {HPV}16 partial genotyping was 36%. {T}he specificities for these tests were 45%, 29%, 72%., and 85%, respectively. {C}ombining {VIA} and/or partial genotyping positivity slightly increased the sensitivity (94%) at the cost of lower specificity (28%). {T}here was significant intersite heterogeneity (p = .04). {A}mong the three triage tests with a sensitivity >= 85%, the {VIA} had the highest specificity and positive likelihood ratio (p < .001). {VIA} and extended genotyping, whether independent or combined, are good triage options with high sensitivity for identifying {WLHIV} needing treatment for {CIN}2+.},
  keywords = {cervical cancer ; {HIV} ; {HPV} ; resource-limited countries ; screening ; {COTE} {D}'{IVOIRE} ; {BURKINA} {FASO} ; {CAMBODGE}},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {C}ancer},
  volume = {156},
  numero = {3},
  pages = {598--607},
  ISSN = {0020-7136},
  year = {2025},
  DOI = {10.1002/ijc.35190},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091397},
}