@article{fdi:010091377,
  title = {{D}e novo evolution of transmissible tumours in hydra},
  author = {{T}issot, {S}. and {M}eliani, {J}. and {B}outry, {J}. and {B}razier, {L}. and {T}{\¨o}k{\¨o}lyi, {J}. and {R}oche, {B}enjamin and {U}jvari, {B}. and {N}edelcu, {A}. {M}. and {T}homas, {F}. and {D}ujon, {A}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}hile most cancers are not transmissible, there are rare cases where cancer cells can spread between individuals and even across species, leading to epidemics. {D}espite their significance, the origins of such cancers remain elusive due to late detection in host populations. {U}sing {H}ydra oligactis, which exhibits spontaneous tumour development that in some strains became vertically transmitted, this study presents the first experimental observation of the evolution of a transmissible tumour. {S}pecifically, we assessed the initial vertical transmission rate of spontaneous tumours and explored the potential for optimizing this rate through artificial selection. {O}ne of the hydra strains, which evolved transmissible tumours over five generations, was characterized by analysis of cell type and bacteriome, and assessment of life-history traits. {O}ur findings indicate that tumour transmission can be immediate for some strains and can be enhanced by selection. {T}he resulting tumours are characterized by overproliferation of large interstitial stem cells and are not associated with a specific bacteriome. {F}urthermore, despite only five generations of transmission, these tumours induced notable alterations in host life-history traits, hinting at a compensatory response. {T}his work, therefore, makes the first contribution to understanding the conditions of transmissible cancer emergence and their short-term consequences for the host.},
  keywords = {neoplasm ; transmissible cancer cells ; experimental evolution ; cnidarian},
  booktitle = {},
  journal = {{P}roceedings of the {R}oyal {S}ociety {B} - {B}iological {S}ciences},
  volume = {291},
  numero = {2031},
  pages = {20241636 [11 ]},
  ISSN = {0962-8452},
  year = {2024},
  DOI = {10.1098/rspb.2024.1636},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091377},
}