@article{fdi:010091338,
  title = {{M}itochondrial variation in {A}nopheles gambiae and {A}nopheles coluzzii : phylogeographic legacy and mitonuclear associations with metabolic resistance to pathogens and insecticides},
  author = {{R}omero, {J}. {E}. {A}. and {C}henal, {C}lothilde and {B}en {C}hehida, {Y}. and {M}iles, {A}. and {C}larkson, {C}. {S}. and {P}edergnana, {V}. and {W}ertheim, {B}. and {F}ontaine, {M}. {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}itochondrial {DNA} has been a popular marker in phylogeography, phylogeny, and molecular ecology, but its complex evolution is increasingly recognized. {H}ere, we investigated mitochondrial {DNA} variation in {A}nopheles gambiae and {A}nopheles coluzzii, in relation to other species in the {A}nopheles gambiae complex, by assembling the mitogenomes of 1,219 mosquitoes across {A}frica. {T}he mitochondrial {DNA} phylogeny of the {A}nopheles gambiae complex was consistent with previously reported highly reticulated evolutionary history, revealing important discordances with the species tree. {T}he three most widespread species ({A}n. gambiae, {A}n. coluzzii, and {A}nopheles arabiensis), known for extensive historical introgression, could not be discriminated based on mitogenomes. {F}urthermore, a monophyletic clustering of the three saltwater-tolerant species ({A}nopheles merus, {A}nopheles melas, and {A}nopheles bwambae) in the {A}nopheles gambiae complex also suggested that introgression and possibly selection shaped mitochondrial {DNA} evolution. {M}itochondrial {DNA} variation in {A}n. gambiae and {A}n. coluzzii across {A}frica revealed significant partitioning among populations and species. {A} peculiar mitochondrial {DNA} lineage found predominantly in {A}n. coluzzii and in the hybrid taxon of the {A}frican "far-west" exhibited divergence comparable to the interspecies divergence in the {A}nopheles gambiae complex, with a geographic distribution matching closely {A}n. coluzzii's geographic range. {T}his phylogeographic relict of the {A}n. coluzzii and {A}n. gambiae split was associated with population and species structure, but not with the rare {W}olbachia occurrence. {T}he lineage was significantly associated with single nucleotide polymorphisms in the nuclear genome, particularly in genes associated with pathogen and insecticide resistance. {T}hese findings underline potential mitonuclear coevolution history and the role played by mitochondria in shaping metabolic responses to pathogens and insecticides in {A}nopheles. {G}raphical abstract {A}nopheles gambiae.},
  keywords = {{A}nopheles gambiae complex ; mitogenome ; mitonuclear coevolution ; phylogeography ; insecticide resistance ; {OXSPHOS}},
  booktitle = {},
  journal = {{G}enome {B}iology and {E}volution},
  volume = {16},
  numero = {9},
  pages = {evae172 [24 ]},
  ISSN = {1759-6653},
  year = {2024},
  DOI = {10.1093/gbe/evae172},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091338},
}