@article{fdi:010091304,
  title = {{E}thnobotany, phytochemistry, and biological activities of {P}sidium guajava in the treatment of diarrhea : a review},
  author = {{L}iu, {C}. {M}. and {J}ullian, {V}al{\'e}rie and {C}hassagne, {F}ran{\c{c}}ois},
  editor = {},
  language = {{ENG}},
  abstract = {{P}sidium guajava: is a tropical tree that is widely used in traditional medicine, especially for treating diarrhea. {W}hile {P}. guajava has been the subject of numerous reviews, none have specifically examined its ethnobotany, pharmacology, and phytochemistry in relation to its antidiarrheal activity. {T}his review aims to summarize the evidence of effectiveness and safety of {P}. guajava in the treatment of diarrhea. {L}iterature searches were conducted through {W}eb of {S}cience, {P}ub{M}ed, and {S}cience{D}irect by using keywords "{P}sidium guajava" and "diarrhea" in {O}ctober 2022. {A} total of 189 studies were included in this review. {P}. guajava is widely used in traditional medicine in 44 countries. {D}ecoction and oral were the most represented method of preparation and administration, respectively, while leaves represented the most frequently cited part of the plant. {A}round 27 antidiarrheal or antibacterial compounds have been isolated and identified, including benzophenone glycosides, terpenes, polysaccharides, phenols, and flavonoids. {T}his article presents ethnobotanical and pharmacological evidence for the efficacy of {P}. guajava leaves in the treatment of diarrhea and provides reference information for further investigation of this plant. {H}owever, despite the large number of publications on the topic, there are still some questions to answer: are quercetin and its glycosides the only ones to act as antidiarrheal agents? {W}hat is the mechanism of action of {P}. guajava antidiarrheal compounds? are the use of guava leaves safe in all types of populations including children, and at what dosage? {T}o answer these questions, more complete phytochemical studies and systematic clinical trials are needed.},
  keywords = {medicinal plants ; guava ; tropical countries ; dysentery ; diarrhea ; literature review ; {P}sidium guajava},
  booktitle = {},
  journal = {{F}rontiers in {P}harmacology},
  volume = {15},
  numero = {},
  pages = {1459066 [18 p.]},
  year = {2024},
  DOI = {10.3389/fphar.2024.1459066},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091304},
}