@article{fdi:010091293,
  title = {{H}igh seroreactivities to orthoebolaviruses in rural {C}ameroon : a case-control study on nonhuman primate bites and a cross-sectional survey in rural populations},
  author = {{R}amassamy, {J}ill-lea and {A}youba, {A}hidjo and {T}haurignac, {G}. and {N}dongo, {C}. {B}. and {N}nuka, {P}. and {B}etsem, {E}. and {N}jouom, {R}. and {N}gole, {E}. {M}. and {V}anhomwegen, {J}. and {H}oinard, {D}. and {E}ngland, {P}. and {J}ourneaux, {A}. and {P}icard, {C}. and {T}homas, {D}. and {P}annetier, {D}. and {B}aize, {S}. and {D}elaporte, {E}. and {P}eeters, {M}artine and {G}essain, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {E}bola ({EBOV}) and {S}udan ({SUDV}) orthoebolaviruses are responsible for lethal hemorrhagic fever outbreaks in humans in {C}entral and {W}est {A}frica, and in apes that can be at the source of human outbreaks for {EBOV}.{M}ethods {T}o assess the risk of exposure to orthoebolaviruses through contact with nonhuman primates ({NHP}), we tested the presence of antibodies against different viral proteins with a microsphere-based multiplex immunoassay in a case-control study on bites from {NHP}s in forest areas from {C}ameroon (n = 795) and in cross-sectional surveys from other rural populations (n = 622) of the same country.{R}esults {S}eroreactivities against at least 2 viral proteins were detected in 13% and 12% of the samples for {EBOV} and {SUDV}, respectively. {P}robability of seroreactivity was not associated with history of {NHP} bites, but was 3 times higher in {P}ygmies compared to {B}antus. {A}lthough no neutralizing antibodies to {EBOV} and {SUDV} were detected in a selected series of highly reactive samples, avidity results indicate strong affinity to {SUDV} antigens.{C}onclusions {T}he detection of high level of seroreactivities against orthoebolaviruses in rural {C}ameroon, where no outbreaks have been reported, raises the possibilities of silent circulation of orthoebolaviruses, or of other not yet documented filoviruses, in these forested regions.{A}rticle's main point {O}ur study found high seroreactivities to {E}bola and {S}udan orthoebolavirus antigens in rural {C}ameroonian populations, especially among {P}ygmies, despite no reported outbreaks. {T}his suggests potential silent circulation of orthoebolaviruses or unknown filoviruses, highlighting the need for further surveillance and research.},
  keywords = {{F}iloviridae ; {E}bola virus ; {S}udan virus ; {C}ameroon ; {C}entral {A}frica ; {CAMEROUN}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[10 p.]},
  ISSN = {0022-1899},
  year = {2024},
  DOI = {10.1093/infdis/jiae399},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091293},
}