@article{fdi:010091286,
  title = {{R}etrotransposon addiction promotes centromere function via epigenetically activated small {RNA}s},
  author = {{S}himada, {A}. and {C}ahn, {J}. and {E}rnst, {E}. and {L}ynn, {J}. and {G}rimanelli, {D}aniel and {H}enderson, {I}. and {K}akutani, {T}. and {M}artienssen, {R}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{R}etrotransposons have invaded eukaryotic centromeres in cycles of repeat expansion and purging, but the function of centromeric retrotransposons has remained unclear. {I}n {A}rabidopsis, centromeric {ATHILA} retrotransposons give rise to epigenetically activated short interfering {RNA}s in mutants in {DECREASE} {IN} {DNA} {METHYLATION}1 ({DDM}1). {H}ere we show that mutants that lose both {DDM}1 and {RNA}-dependent {RNA} polymerase have pleiotropic developmental defects and mis-segregate chromosome 5 during mitosis. {F}ertility and segregation defects are epigenetically inherited with centromere 5, and can be rescued by directing artificial small {RNA}s to {ATHILA}5 retrotransposons that interrupt tandem satellite repeats. {E}pigenetically activated short interfering {RNA}s promote pericentromeric condensation, chromosome cohesion and chromosome segregation in mitosis. {W}e propose that insertion of {ATHILA} silences centromeric transcription, while simultaneously making centromere function dependent on retrotransposon small {RNA}s in the absence of {DDM}1. {P}arallels are made with the fission yeast {S}chizosaccharomyces pombe, where chromosome cohesion depends on {RNA} interference, and with humans, where chromosome segregation depends on both {RNA} interference and {HELLSDDM}1. {C}entromeric satellite repeats on {A}rabidopsis chromosome 5 are interrupted by {ATHILA}5 retrotransposons, and cohesion is compromised in ddm1 chromatin remodelling mutants that have also lost {RNA}i. {M}is-segregation is epigenetically inherited but can be rescued by {ATHILA}5 small {RNA}.},
  keywords = {},
  booktitle = {},
  journal = {{N}ature {P}lants},
  volume = {10},
  numero = {},
  pages = {1304--1316 + [13 p.]},
  ISSN = {2055-026{X}},
  year = {2024},
  DOI = {10.1038/s41477-024-01773-1},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091286},
}