@article{fdi:010091206,
  title = {{M}ajor depletion of insulin sensitivity-associated taxa in the gut microbiome of persons living with {HIV} controlled by antiretroviral drugs},
  author = {{B}elda, {E}ugeni and {C}apeau, {J}. and {Z}ucker, {J}ean-{D}aniel and {L}e {C}hatelier, {E}. and {P}ons, {N}. and {O}ñate, {F}. {P}. and {Q}uinquis, {B}. and {A}lili, {R}. and {F}ellahi, {S}. and {K}atlama, {C}. and {C}l{\'e}ment, {K}. and {F}{\`e}ve, {B}. and {J}aureguiberry, {S}. and {G}oujard, {C}. and {L}ambotte, {O}. and {D}or{\'e}, {J}. and {P}rifti, {E}di and {B}astard, {J}. {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {P}ersons living with {HIV} ({PWH}) harbor an altered gut microbiome (higher abundance of {P}revotella and lower abundance of {B}acillota and {R}uminococcus lineages) compared to non-infected individuals. {S}ome of these alterations are linked to sexual preference and others to the {HIV} infection. {T}he relationship between these lineages and metabolic alterations, often present in aging {PWH}, has been poorly investigated. {M}ethods {I}n this study, we compared fecal metagenomes of 25 antiretroviral-treatment ({ART})-controlled {PWH} to three independent control groups of 25 non-infected matched individuals by means of univariate analyses and machine learning methods. {M}oreover, we used two external datasets to validate predictive models of {PWH} classification. {N}ext, we searched for associations between clinical and biological metabolic parameters with taxonomic and functional microbiome profiles. {F}inally, we compare the gut microbiome in 7 {PWH} after a 17-week {ART} switch to raltegravir/maraviroc. {R}esults{T}hree major enterotypes ({P}revotella, {B}acteroides and {R}uminococcaceae) were present in all groups. {T}he first {P}revotella enterotype was enriched in {PWH}, with several of characteristic lineages associated with poor metabolic profiles (low {HDL} and adiponectin, high insulin resistance ({HOMA}-{IR})). {C}onversely butyrate-producing lineages were markedly depleted in {PWH} independently of sexual preference and were associated with a better metabolic profile (higher {HDL} and adiponectin and lower {HOMA}-{IR}). {A}ccordingly with the worst metabolic status of {PWH}, butyrate production and amino-acid degradation modules were associated with high {HDL} and adiponectin and low {HOMA}-{IR}. {R}andom {F}orest models trained to classify {PWH} vs. control on taxonomic abundances displayed high generalization performance on two external holdout datasets ({ROC} {AUC} of 80-82%). {F}inally, no significant alterations in microbiome composition were observed after switching to raltegravir/maraviroc. {C}onclusion {H}igh resolution metagenomic analyses revealed major differences in the gut microbiome of {ART}-controlled {PWH} when compared with three independent matched cohorts of controls. {T}he observed marked insulin resistance could result both from enrichment in {P}revotella lineages, and from the depletion in species producing butyrate and involved into amino-acid degradation, which depletion is linked with the {HIV} infection.},
  keywords = {{HIV} ; {H}uman gut microbiome ; {M}etabolic status ; {M}achine learning},
  booktitle = {},
  journal = {{BMC} {M}edical {G}enomics},
  volume = {17},
  numero = {1},
  pages = {209 [21 p.]},
  year = {2024},
  DOI = {10.1186/s12920-024-01978-5},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091206},
}