@article{fdi:010091136,
  title = {{N}on-contact detection of pyrethroids widely used in vector control by {A}nopheles mosquitoes},
  author = {{K}ambou, {S}. {S}. and {V}alente, {A}deline and {A}gnew, {P}. and {H}ien, {D}. {F}. {D}. and {Y}erbanga, {R}. {S}. and {M}oiroux, {N}icolas and {D}abire, {K}. {R}. and {P}ennetier, {C}{\'e}dric and {C}ohuet, {A}nna and {C}arrasco, {D}avid},
  editor = {},
  language = {{ENG}},
  abstract = {{P}yrethroids are the most widely used insecticides to control vector borne diseases including malaria. {P}hysiological resistance mechanisms to these insecticides have been well described, whereas those for behavioral resistance remain overlooked. {F}ield data suggest the presence of spatial sensory detection by {A}nopheles mosquitoes of the pyrethroid molecules used in insecticide-based control tools, such as long-lasting insecticide nets or insecticide residual spraying. {T}his opens the way to the emergence of a wide range of behavioral adaptations among malaria vectors. {H}owever, the spatial sensory detection of these molecules is controversial and needs to be demonstrated. {T}he goal of this study was to behaviorally characterize the non-contact detection of three of the most common pyrethroids used for malaria vector control: permethrin, deltamethrin an alpha-cypermethrin. {T}o reach this goal, we recorded the behavior (takeoff response) of {A}nopheles gambiae pyrethroid-sensitive and resistant laboratory strains, as well as field collected mosquitoes from the {G}ambiae {C}omplex, when exposed to the headspace of bottles containing different doses of the insecticides at 25 and 35 degrees {C}, in order to represent a range of laboratory and field temperatures. {W}e found the proportion of laboratory susceptible and resistant female mosquitoes that took off was, in all treatments, dose and the temperature dependent. {S}ensitive mosquitoes were significantly more prone to take off only in the presence of alpha-cypermethrin, whereas sensitive and resistant mosquitoes showed similar responses to permethrin and deltamethrin. {F}ield-collected mosquitoes of the {G}ambiae {C}omplex were also responsive to permethrin, independently of the species identity ({A}n. gambiae, {A}n. coluzzii and {A}n. arabiensis) or their genotypes for the kdr mutation, known to confer resistance to pyrethroids. {T}he observed ability of {A}nopheles spp. mosquitoes to detect insecticides without contact could favor the evolution of behavioral modifications that may allow them to avoid or reduce the adverse effect of insecticides and thus, the development of behavioral resistance.},
  keywords = {{AFRIQUE} {SUBSAHARIENNE} ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {19},
  numero = {7},
  pages = {e0298512 [15 ]},
  ISSN = {1932-6203},
  year = {2024},
  DOI = {10.1371/journal.pone.0298512},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091136},
}