Faecal microbiota of schoolchildren is associated with nutritional status and markers of inflammation : a double-blinded cluster-randomized controlled trial using multi-micronutrient fortified rice Seyoum Y. auteur aut IRD Greffeuille V. auteur aut IRD Kouadio D. K. D. auteur aut IRD Kuong K. auteur aut IRD Turpin W. auteur aut IRD M'Rabt R. auteur aut IRD Chochois V. auteur aut IRD Fortin Sonia auteur aut IRD Perignon M. auteur aut IRD Fiorentino Marion auteur aut IRD Berger Jacques auteur aut IRD Burja K. auteur aut IRD Ponce M. C. auteur aut IRD Chamnan C. auteur aut IRD Wieringa Franck auteur aut IRD Humblot Christèle auteur aut IRD text journalArticle eng text/pdf reformatted digital access Faecal microbiota plays a critical role in human health, but its relationship with nutritional status among schoolchildren remains under-explored. Here, in a double-blinded cluster-randomized controlled trial on 380 Cambodian schoolchildren, we characterize the impact of six months consumption of two types of rice fortified with different levels of vitamins and minerals on pre-specified outcomes. We investigate the association between the faecal microbiota (16SrRNA sequencing) and age, sex, nutritional status (underweight, stunting), micronutrient status (iron, zinc and vitamin A deficiencies, anaemia, iron deficient anaemia, hemoglobinopathy), inflammation (systemic, gut), and parasitic infection. We show that the faecal microbiota is characterised by a surprisingly high proportion of Lactobacillaceae. We discover that deficiencies in specific micronutrients, such as iron and vitamin A, correlate with particular microbiota profiles, whereas zinc deficiency shows no such association. The nutritional intervention with the two rice treatments impacts both the composition and functions predicted from compositional analysis in different ways. (ClinicalTrials.gov (Identifier: NCT01706419)) Here, in, the authors investigate the relationship between fecal microbiota and nutritional status in a trial on 380 Cambodian schoolchildren, establishing a correlation between micronutrient deficiencies and microbiota profiles. specialized CAMBODGE 054 084 Nature Communications 15 1 5204 [12 ] 2024 https://www.documentation.ird.fr/hor/fdi:010091128 10.1038/s41467-024-49093-4 [F B010091128] https://www.documentation.ird.fr/hor/fdi:010091128 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2024-09/010091128.pdf IRD - Base Horizon / Pleins textes 2024-09-27 2025-11-06 fdi:010091128 fre