@article{fdi:010091128,
  title = {{F}aecal microbiota of schoolchildren is associated with nutritional status and markers of inflammation : a double-blinded cluster-randomized controlled trial using multi-micronutrient fortified rice},
  author = {{S}eyoum, {Y}. and {G}reffeuille, {V}. and {K}ouadio, {D}. {K}. {D}. and {K}uong, {K}. and {T}urpin, {W}. and {M}'{R}abt, {R}. and {C}hochois, {V}. and {F}ortin, {S}onia and {P}erignon, {M}. and {F}iorentino, {M}arion and {B}erger, {J}acques and {B}urja, {K}. and {P}once, {M}. {C}. and {C}hamnan, {C}. and {W}ieringa, {F}ranck and {H}umblot, {C}hrist{\`e}le},
  editor = {},
  language = {{ENG}},
  abstract = {{F}aecal microbiota plays a critical role in human health, but its relationship with nutritional status among schoolchildren remains under-explored. {H}ere, in a double-blinded cluster-randomized controlled trial on 380 {C}ambodian schoolchildren, we characterize the impact of six months consumption of two types of rice fortified with different levels of vitamins and minerals on pre-specified outcomes. {W}e investigate the association between the faecal microbiota (16{S}r{RNA} sequencing) and age, sex, nutritional status (underweight, stunting), micronutrient status (iron, zinc and vitamin {A} deficiencies, anaemia, iron deficient anaemia, hemoglobinopathy), inflammation (systemic, gut), and parasitic infection. {W}e show that the faecal microbiota is characterised by a surprisingly high proportion of {L}actobacillaceae. {W}e discover that deficiencies in specific micronutrients, such as iron and vitamin {A}, correlate with particular microbiota profiles, whereas zinc deficiency shows no such association. {T}he nutritional intervention with the two rice treatments impacts both the composition and functions predicted from compositional analysis in different ways. ({C}linical{T}rials.gov ({I}dentifier: {NCT}01706419)) {H}ere, in, the authors investigate the relationship between fecal microbiota and nutritional status in a trial on 380 {C}ambodian schoolchildren, establishing a correlation between micronutrient deficiencies and microbiota profiles.},
  keywords = {{CAMBODGE}},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {15},
  numero = {1},
  pages = {5204 [12 ]},
  year = {2024},
  DOI = {10.1038/s41467-024-49093-4},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091128},
}