%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Hounmenou, C. G.
%A Le Marcis, Frédéric
%A Kaba, D.
%A Diaby, M.
%A Soumah, A. K.
%A Diallo, H.
%A Thaurignac, G.
%A Camara, S. C.
%A Ayouba, Ahidjo
%A Peeters, Martine
%A Keita, A. K.
%A Delaporte, E.
%A Toure, A.
%T Ebola virus circulation in a non-epidemic Guinean rural area : a mixed-method approach to assessing endemicity
%D 2024
%L fdi:010091079
%G ENG
%J International Journal of Infectious Diseases
%@ 1201-9712
%K Ebola virus disease ; Seroprevalence ; Guinea rural population ; Outbreak ; Surveillance strategies
%K GUINEE
%M ISI:001266474300001
%P 107129 [8 ]
%R 10.1016/j.ijid.2024.107129
%U https://www.documentation.ird.fr/hor/fdi:010091079
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2024-09/010091079.pdf
%V 146
%W Horizon (IRD)
%X Objectives: This study aimed to investigate the prevalence of orthoebolavirus antibodies in Madina Oula, a non-epidemic rural area in Guinea, in 2022. Methods: A cross-sectional study was conducted from March 14 to April 3, 2022 involving recording household and socio-demographic characteristics, lifestyle data, and collecting dried blood spots from 878 individuals in 235 households. Dried blood spots were tested using multiplex serology to detect antibodies to different orthoebolaviruses : Ebola virus, Bundibugyo virus, Sudan virus, Reston virus, and Bombali virus. Seroprevalence was estimated with a 95% confidence interval and a Z-test was performed to compare the seropositivity between children aged under 15 years and those over 15 years . Household and participant characteristics were analyzed using descriptive statistic, and socio-historical conditions were discussed. Results: The serological analysis conducted in 2022 on 878 participants revealed varying reactivity to orthoebolavirus antigens, notably, with glycoprotein antigens, particularly, glycoprotein Sudan virus (16%). A total of 21 samples exhibited reactivity with at least two antigens, with a median age of 27 years (interquartile range 10.0 0-35.0 0), ranging from 2 to 80 years. There is no significant difference between seropositivity in children aged under 15 (2.86%) years and those over 15 (2.14%) years. The antibody presence varied per village, with the highest prevalence observed in Ouassou and Dar-es-Salam. Conclusions: Serological data in a region unaffected by recent Ebola outbreaks indicate possible orthoebolavirus endemicity, emphasizing the need for preparedness against known or novel orthoebolaviruses with potential cross-reactivity.
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