@article{fdi:010091079,
  title = {{E}bola virus circulation in a non-epidemic {G}uinean rural area : a mixed-method approach to assessing endemicity},
  author = {{H}ounmenou, {C}. {G}. and {L}e {M}arcis, {F}r{\'e}d{\'e}ric and {K}aba, {D}. and {D}iaby, {M}. and {S}oumah, {A}. {K}. and {D}iallo, {H}. and {T}haurignac, {G}. and {C}amara, {S}. {C}. and {A}youba, {A}hidjo and {P}eeters, {M}artine and {K}eita, {A}. {K}. and {D}elaporte, {E}. and {T}oure, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives: {T}his study aimed to investigate the prevalence of orthoebolavirus antibodies in {M}adina {O}ula, a non-epidemic rural area in {G}uinea, in 2022. {M}ethods: {A} cross-sectional study was conducted from {M}arch 14 to {A}pril 3, 2022 involving recording household and socio-demographic characteristics, lifestyle data, and collecting dried blood spots from 878 individuals in 235 households. {D}ried blood spots were tested using multiplex serology to detect antibodies to different orthoebolaviruses : {E}bola virus, {B}undibugyo virus, {S}udan virus, {R}eston virus, and {B}ombali virus. {S}eroprevalence was estimated with a 95% confidence interval and a {Z}-test was performed to compare the seropositivity between children aged under 15 years and those over 15 years . {H}ousehold and participant characteristics were analyzed using descriptive statistic, and socio-historical conditions were discussed. {R}esults: {T}he serological analysis conducted in 2022 on 878 participants revealed varying reactivity to orthoebolavirus antigens, notably, with glycoprotein antigens, particularly, glycoprotein {S}udan virus (16%). {A} total of 21 samples exhibited reactivity with at least two antigens, with a median age of 27 years (interquartile range 10.0 0-35.0 0), ranging from 2 to 80 years. {T}here is no significant difference between seropositivity in children aged under 15 (2.86%) years and those over 15 (2.14%) years. {T}he antibody presence varied per village, with the highest prevalence observed in {O}uassou and {D}ar-es-{S}alam. {C}onclusions: {S}erological data in a region unaffected by recent {E}bola outbreaks indicate possible orthoebolavirus endemicity, emphasizing the need for preparedness against known or novel orthoebolaviruses with potential cross-reactivity.},
  keywords = {{E}bola virus disease ; {S}eroprevalence ; {G}uinea rural population ; {O}utbreak ; {S}urveillance strategies ; {GUINEE}},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {I}nfectious {D}iseases},
  volume = {146},
  numero = {},
  pages = {107129 [8 ]},
  ISSN = {1201-9712},
  year = {2024},
  DOI = {10.1016/j.ijid.2024.107129},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091079},
}