@article{fdi:010091068,
  title = {{SARS}-{C}o{V}-2 seroprevalence among {B}eninese pregnant women in the third year of the pandemic},
  author = {{F}igueroa-{R}omero, {A}. and {A}tchad{\'e}, {A}. and {Y}adouleton, {A}. and {F}iogbe, {M}. and {B}onnet, {E}mmanuel and {Y}ovo, {E}. and {A}ccrombessi, {M}. and {H}ounsa, {S}. and {P}aper, {T}. and {D}upont, {R}. and {G}audart, {J}. and {L}e {H}esran, {J}ean-{Y}ves and {M}assougbodji, {A}. and {C}ottrell, {G}illes and {G}onzález, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {P}regnant women are a vulnerable population to {COVID}-19 given an increased susceptibility to severe {SARS}-{C}o{V}-2 infection and pregnancy complications. {H}owever, few {SARS}-{C}o{V}-2 serological surveys have been performed among this population to assess the extent of the infection in sub-{S}aharan countries. {T}he objectives of this study were to determine {SARS}-{C}o{V}-2 seroprevalence among {B}eninese pregnant women, to identify spatial seropositivity clusters and to analyse factors associated with the infection.{M}ethods{A} cross-sectional study including women in their third trimester of pregnancy attending the antenatal care ({ANC}) clinics at {A}llada (south {B}enin) and {N}atitingou (north {B}enin) was conducted. {R}apid diagnostic tests ({RDT}) for detection of {I}g{G}/{I}g{M} against the {SARS}-{C}o{V}-2 spike protein were performed using capillary blood. {S}eroprevalence of {SARS}-{C}o{V}-2 antibodies and associations between {SARS}-{C}o{V}-2 serostatus and maternal characteristics were analyzed by multivariate logistic regression. {S}patial analyses were performed using the spatial scan statistics to identify spatial clusters of {SARS}-{C}o{V}-2 infection.{R}esults{A} total of 861 pregnant women were enrolled between {M}ay 4 and {J}une 29, 2022. 58/861 (6.7%) participants reported having received {COVID}-19 vaccine. {N}one of the participants had been diagnosed with {COVID}-19 during their pregnancy. {SARS}-{C}o{V}-2 antibodies were detected in 607/802 (75.7%; 95% {CI} 72.56%-78.62%) of unvaccinated participants. {S}everal urban and rural spatial clusters of {SARS}-{C}o{V}-2 cases were identified in {A}llada and one urban spatial cluster was identified in {N}atitingou. {U}nvaccinated participants from {A}llada with at least one previous morbidity were at a three-times higher risk of presenting {SARS}-{C}o{V}-2 antibodies ({OR} = 2.89; 95%{CI} 1.19%-7.00%).{C}onclusion {T}hree out of four pregnant women had {SARS}-{C}o{V}-2 antibodies, suggesting a high virus circulation among pregnant women in {B}enin, while {COVID}-19 vaccination coverage was low. {P}regnant women with comorbidities may be at increased risk of {SARS}-{C}o{V}-2 infection. {T}his population should be prioritized for {COVID}-19 diagnosis and vaccination in order to prevent its deleterious effects.{T}rial registration {NCT}06170320 (retrospectively registered on {D}ecember 21, 2023).},
  keywords = {{P}regnancy ; {SARS}-{C}o{V}-2 ; {S}ub-saharan {A}frica ; {BENIN} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{BMC} {P}ublic {H}ealth},
  volume = {24},
  numero = {1},
  pages = {1762 [9 p.]},
  year = {2024},
  DOI = {10.1186/s12889-024-19087-4},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091068},
}