@article{fdi:010090761,
  title = {{O}xidative potential of particulate matter and its association to respiratory health endpoints in high-altitude cities in {B}olivia},
  author = {{B}orlaza-{L}acoste, {L}. and {M}ardoñez, {V}. and {M}arsal, {A}nouk and {H}ough, {I}. and {D}inh, {V}. {N}. {T}. and {D}ominutti, {P}. and {J}affrezo, {J}. {L}. and {A}lastuey, {A}. and {B}esombes, {J}. {L}. and {M}ocnik, {G}. and {M}oreno, {I}. and {V}elarde, {F}. and {G}ardon, {J}acques and {C}ornejo, {A}. and {A}ndrade, {M}. and {L}aj, {P}. and {U}zu, {G}a{\¨e}lle},
  editor = {},
  language = {{ENG}},
  abstract = {{E}xposure to particulate matter ({PM}) pollution is a significant health risk, driving the search for innovative metrics that more accurately reflect the potential harm to human health. {A}mong these, oxidative potential ({OP}) has emerged as a promising health-based metric, yet its application and relevance across different environments remain to be further explored. {T}his study, set in two high-altitude {B}olivian cities, aims to identify the most significant sources of {PM}-induced oxidation in the lungs and assess the utility of {OP} in assessing {PM} health impacts. {U}tilizing two distinct assays, {OPDTT} and {OPDCFH}, we measured the {OP} of {PM} samples, while also examining the associations between {PM} mass, {OP}, and black carbon ({BC}) concentrations with hospital visits for acute respiratory infections ({ARI}) and pneumonia over a range of exposure lags (0-2 weeks) using a {P}oisson regression model adjusted for meteorological conditions. {T}he analysis also leveraged {P}ositive {M}atrix {F}actorization ({PMF}) to link these health outcomes to specific {PM} sources, building on a prior source apportionment study utilizing the same dataset. {O}ur findings highlight anthropogenic combustion, particularly from traffic and biomass burning, as the primary contributors to {OP} in these urban sites. {S}ignificant correlations were observed between both {OPDTT} and {PM}2.5 concentration exposure and {ARI} hospital visits, alongside a notable association with pneumonia cases and {OPDTT} levels. {F}urthermore, {PMF} analysis demonstrated a clear link between trafficrelated pollution and increased hospital admissions for respiratory issues, affirming the health impact of these sources. {T}hese results underscore the potential of {OPDTT} as a valuable metric for assessing the health risks associated with acute {PM} exposure, showcasing its broader application in environmental health studies.},
  keywords = {{P}articulate matter ; {O}xidative potential ; {R}espiratory health ; {B}olivia ; {S}ource apportionment ; {P}ositive matrix factorization ; {P}oisson regression ; {BOLIVIE}},
  booktitle = {},
  journal = {{E}nvironmental {R}esearch},
  volume = {255},
  numero = {},
  pages = {119179 [11 ]},
  ISSN = {0013-9351},
  year = {2024},
  DOI = {10.1016/j.envres.2024.119179},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090761},
}