@article{fdi:010090722,
  title = {{E}fficient transplacental transfer of {SARS}-{C}o{V}-2 antibodies between naturally exposed mothers and infants in {A}ccra, {G}hana},
  author = {{P}artey, {F}. {D}. and {O}biri, {D}. and {B}onney, {E}. {Y}. and {P}obee, {A}. {N}. {A}. and {D}amptey, {I}. {K}. and {E}nnuson, {K}. and {A}kwetea-{F}oli, {J}. and {N}uokpem, {F}. {Y}. and {C}ourtin, {D}avid and {K}usi, {K}. {A}. and {M}ensah, {B}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e aimed to determine {SARS}-{C}o{V}-2 antibody seropositivity among pregnant women and the transplacental transfer efficiency of {SARS}-{C}o{V}-2-specific antibodies relative to malaria antibodies among {SARS}-{C}o{V}-2 seropositive mother-cord pairs. {T}his cross-sectional study was conducted in {A}ccra, {G}hana, from {M}arch to {M}ay 2022. {A}ntigen- specific {I}g{G} antibodies against {SARS}-{C}o{V}-2 (nucleoprotein and spike-receptor binding domain) and malarial antigens (circumsporozoite protein and merozoite surface protein 3) in maternal and cord plasma were measured by {ELISA}. {P}lasma from both vaccinated and unvaccinated pregnant women were tested for neutralizing antibodies using commercial kit. {O}f the unvaccinated pregnant women tested, 58.12% at antenatal clinics and 55.56% at the delivery wards were seropositive for both {SARS}-{C}o{V}-2 nucleoprotein and {RBD} antibodies. {A}nti-{SARS}-{C}o{V}-2 antibodies in cord samples correlated with maternal antibody levels ({N} antigen r(s) = 0.7155, p < 0.001; {RBD} r(s) = 0.8693, p < 0.001). {T}ransplacental transfer of {SARS}-{C}o{V}-2 nucleoprotein antibodies was comparable to circumsporozoite protein antibodies (p = 0.9999) but both were higher than transfer rates of merozoite surface protein 3 antibodies (p < 0.001). {SARS}-{C}o{V}-2 {I}g{G} seropositivity among pregnant women in {A}ccra is high with a boost of {SARS}-{C}o{V}-2 {RBD}-specific {I}g{G} in vaccinated women. {T}ransplacental transfer of anti-{SARS}-{C}o{V}-2 and malarial antibodies was efficient, supporting vaccination of mothers as a strategy to protect infants against {SARS}-{C}o{V}-2.},
  keywords = {{COVID}-19 ; {SARS}-{COV}-2 ; {M}aternal {COVID}-19 ; {P}renatal {COVID}-19 placental ; transfer ; {T}ransfer efficiency ; {GHANA}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {14},
  numero = {1},
  pages = {10772 [10 p.]},
  ISSN = {2045-2322},
  year = {2024},
  DOI = {10.1038/s41598-024-61496-3},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090722},
}