@article{fdi:010090710,
  title = {{I}nfected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria},
  author = {{F}raering, {J}eremy and {S}alnot, {V}. and {G}autier, {E}. {F}. and {E}zinmegnon, {S}. and {A}rgy, {N}. and {P}eoc'h, {K}. and {M}anceau, {H}. and {A}lao, {J}. and {G}uillonneau, {F}. and {M}igot {N}abias, {F}lorence and {B}ertin, {G}wladys and {K}amaliddin, {C}. and {A}ubouy, {A}gn{\`e}s and {A}ffolabi, {D}. and {B}iokou, {B}. and {C}ot, {M}ichel and {D}egbelo, {J}. {E}. and {D}eloron, {P}hilippe and {D}ramane, {L}. and {F}aucher, {J}. {F}. and {G}uillochon, {E}. and {H}ouz{\'e}, {L}. and {G}uemouri, {S}ayeh and {H}ouze. {S}. and {J}oste, {V}. and {L}abrunie, {A}. and {L}adipo, {Y}. and {L}athiere, {T}. and {M}assougbodji, {A}. and {M}owendabeka, {A}. and {P}apin, {J}. and {P}ipy, {B}. and {P}reux, {P}. {M}. and {R}aymondeau, {M}. and {R}oyo, {J}. and {S}ossou, {D}. and {T}echer, {B}. and {V}ianou, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}erebral malaria ({CM}), the most lethal complication of {P}lasmodium falciparum severe malaria ({SM}), remains fatal for 15-25% of affected children despite the availability of treatment. {P}. falciparum infects and multiplies in erythrocytes, contributing to anemia, parasite sequestration, and inflammation. {A}n unbiased proteomic assessment of infected erythrocytes and plasma samples from 24 {B}eninese children was performed to study the complex mechanisms underlying {CM}. {A} significant down-regulation of proteins from the ubiquitin-proteasome pathway and an up-regulation of the erythroid precursor marker transferrin receptor protein 1 ({TFRC}) were associated with infected erythrocytes from {CM} patients. {A}t the plasma level, the samples clustered according to clinical presentation. {S}ignificantly, increased levels of the 20{S} proteasome components were associated with {SM}. {T}argeted quantification assays confirmed these findings on a larger cohort (n = 340). {T}hese findings suggest that parasites causing {CM} preferentially infect reticulocytes or erythroblasts and alter their maturation. {I}mportantly, the host plasma proteome serves as a specific signature of {SM} and presents a remarkable opportunity for developing innovative diagnostic and prognostic biomarkers.},
  keywords = {{C}erebral {M}alaria ; {LC}-{MS}/{MS} ; {P}lasmodium falciparum ; {B}iomarkers ; {R}ed {B}lood ; {C}ells ; {BENIN}},
  booktitle = {},
  journal = {{EMBO} {M}olecular {M}edicine},
  volume = {16},
  numero = {2},
  pages = {319--333},
  ISSN = {1757-4676},
  year = {2024},
  DOI = {10.1038/s44321-023-00010-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090710},
}