%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Thu, A. M.
%A Phyo, A. P.
%A Pateekhum, C.
%A Rae, J. D.
%A Landier, Jordi
%A Parker, D. M.
%A Delmas, G.
%A Watthanaworawit, W.
%A McLean, A. R. D.
%A Arya, A.
%A Reyes, A.
%A Li, X.
%A Miotto, O.
%A Soe, K.
%A Ashley, E. A.
%A Dondorp, A.
%A White, N. J.
%A Day, N. P.
%A Anderson, T. J. C.
%A Imwong, M.
%A Nosten, F.
%A Smithuis, F.
%T Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar
%D 2024
%L fdi:010090641
%G ENG
%J Malaria Journal
%K P. falciparum ; Mass drug administration ; Kelch13 ; Artemisinin ; resistance ; Malaria elimination
%K MYANMAR
%M ISI:001216286800002
%N 1
%P 138 [11 ]
%R 10.1186/s12936-024-04955-6
%U https://www.documentation.ird.fr/hor/fdi:010090641
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2024-06/010090641.pdf
%V 23
%W Horizon (IRD)
%X Background Artemisinin resistance in Plasmodium falciparum threatens global malaria elimination efforts. To contain and then eliminate artemisinin resistance in Eastern Myanmar a network of community-based malaria posts was instituted and targeted mass drug administration (MDA) with dihydroartemisinin-piperaquine (three rounds at monthly intervals) was conducted. The prevalence of artemisinin resistance during the elimination campaign (2013-2019) was characterized. Methods Throughout the six-year campaign Plasmodium falciparum positive blood samples from symptomatic patients and from cross-sectional surveys were genotyped for mutations in kelch-13-a molecular marker of artemisinin resistance. Result The program resulted in near elimination of falciparum malaria. Of 5162 P. falciparum positive blood samples genotyped, 3281 (63.6%) had K13 mutations. The prevalence of K13 mutations was 73.9% in 2013 and 64.4% in 2019. Overall, there was a small but significant decline in the proportion of K13 mutants (p < 0.001). In the MDA villages there was no significant change in the K13 proportions before and after MDA. The distribution of different K13 mutations changed substantially; F446I and P441L mutations increased in both MDA and non-MDA villages, while most other K13 mutations decreased. The proportion of C580Y mutations fell from 9.2% (43/467) before MDA to 2.3% (19/813) after MDA (p < 0.001). Similar changes occurred in the 487 villages where MDA was not conducted. Conclusion The malaria elimination program in Kayin state, eastern Myanmar, led to a substantial reduction in falciparum malaria. Despite the intense use of artemisinin-based combination therapies, both in treatment and MDA, this did not select for artemisinin resistance.
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