@article{fdi:010090596,
  title = {{W}orkflow to facilitate the detection of new psychoactive substances and drugs of abuse in influent urban wastewater},
  author = {{B}ade, {R}. and van {H}erwerden, {D}. and {R}ousis, {N}. and {A}dhikari, {S}. and {A}llen, {D}. and {B}aduel, {C}hristine and {B}ijlsma, {L}. and {B}oogaerts, {T}. and {B}urgard, {D}. and {C}happell, {A}. and {D}river, {E}. {M}. and {S}odre, {F}. {F}. and {F}atta-{K}assinos, {D}. and {G}racia-{L}or, {E}. and {G}racia-{M}arín, {E}. and {H}alden, {R}. {U}. and {H}eath, {E}. and {J}aunay, {E}. and {K}rotulski, {A}. and {L}ai, {F}. {Y}. and {L}{\¨o}ve, {A}. {S}. {C}. and {O}'{B}rien, {J}. {W}. and {O}h, {J}. {E}. and {P}asin, {D}. and {C}astro, {M}. {P}. and {P}sichoudaki, {M}. and {S}algueiro-{G}onzalez, {N}. and {G}omes, {C}. {S}. and {S}ubedi, {B}. and {T}homas, {K}. {V}. and {T}homaidis, {N}. and {W}ang, {D}. {G}. and {Y}argeau, {V}. and {S}amanipour, {S}. and {M}ueller, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he complexity around the dynamic markets for new psychoactive substances ({NPS}) forces researchers to develop and apply innovative analytical strategies to detect and identify them in influent urban wastewater. {I}n this work a comprehensive suspect screening workflow following liquid chromatography - high resolution mass spectrometry analysis was established utilising the open -source {I}n{S}pectra data processing platform and the {H}igh{R}es{NPS} library. {I}n total, 278 urban influent wastewater samples from 47 sites in 16 countries were collected to investigate the presence of {NPS} and other drugs of abuse. {A} total of 50 compounds were detected in samples from at least one site. {M}ost compounds found were prescription drugs such as gabapentin (detection frequency 79%), codeine (40%) and pregabalin (15%). {H}owever, cocaine was the most found illicit drug (83%), in all countries where samples were collected apart from the {R}epublic of {K}orea and {C}hina. {E}ight {NPS} were also identified with this protocol: 3-methylmethcathinone 11%), eutylone (6%), etizolam (2%), 3-chloromethcathinone (4%), mitragynine (6%), phenibut (2%), 25{I}-{NBOH} (2%) and trimethoxyamphetamine (2%). {T}he latter three have not previously been reported in municipal wastewater samples. {T}he workflow employed allowed the prioritisation of features to be further investigated, reducing processing time and gaining in confidence in their identification.},
  keywords = {{S}uspect screening ; {H}igh-resolution mass spectrometry ; {I}llicit drugs ; {W}astewater-based epidemiology ; {N}ew {P}sychoactive {S}ubstances ; {AUSTRALIE} ; {BELGIQUE} ; {BRESIL} ; {CANADA} ; {CHINE} ; {CHYPRE} ; {FRANCE} ; {GRECE} ; {ISLANDE} ; {ITALIE} ; {NOUVELLE} {ZELANDE} ; {COREE} {DU} {SUD} ; {SLOVENIE} ; {ESPAGNE} ; {SUEDE} ; {ETATS} {UNIS}},
  booktitle = {},
  journal = {{J}ournal of {H}azardous {M}aterials},
  volume = {469},
  numero = {},
  pages = {133955 [11 p.]},
  ISSN = {0304-3894},
  year = {2024},
  DOI = {10.1016/j.jhazmat.2024.133955},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090596},
}