@article{fdi:010090588,
  title = {{S}nakebites in {C}ameroon : tolerance of a snake antivenom ({I}noserp{TM} {PAN}-{AFRICA}) in {A}frica in real-life conditions},
  author = {{B}enhammou, {D}. and {C}hippaux, {J}ean-{P}hilippe and {N}tone, {R}. and {M}adec, {Y}. and {A}mta, {P}. and {N}oel, {G}. and {K}arl, {F}. {N}. and {P}erilhou, {A}. and {M}atchim, {L}. and {S}anchez, {M}. and {N}difon, {M}. and {C}lauteaux, {P}. and {E}teki, {L}. and {B}oum, {Y}., {II} and {N}kwescheu, {A}. {S}. and {T}aieb, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}nakebite envenomation ({SBE}) is a public health issue in sub-{S}aharan countries. {A}ntivenom is the only etiological treatment. {E}xcellent tolerance is essential in managing {SBE} successfully. {T}his study aimed to evaluate tolerance of {I}noserp{TM} {PAN}-{AFRICA} ({IPA}). {I}t was conducted on fourteen sites across {C}ameroon. {IPA} was administered intravenously and repeated at the same dose every two hours if needed. {E}arly and late tolerance was assessed by the onset of clinical signs within two hours and at a visit two weeks or more after the first {IPA} administration, respectively. {O}ver 20 months, 447 patients presenting with a snakebite were included. {O}ne dose of {IPA} was administered to 361 patients and repeated at least once in 106 patients. {N}o significant difference was shown between the proportion of adverse events in patients who received {IPA} (266/361, 73.7%) and those who did not (69/85, 81.2%) (p = 0.95). {A}dverse reactions, probably attributable to {IPA}, were identified in four (1.1%) patients, including one severe (angioedema) and three mild. {A}ll these reactions resolved favorably. {N}one of the serious adverse events observed in twelve patients were attributed to {IPA}. {N}o signs of late intolerance were observed in 302 patients. {T}olerance appears to be satisfactory. {T}he availability of effective and well-tolerated antivenoms would reduce the duration of treatment and prevent most disabilities and/or deaths.},
  keywords = {snakebite ; envenomation ; antivenom ; tolerance ; sub-{S}aharan {A}frica ; {C}ameroon ; treatment ; {CAMEROUN} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{T}oxins},
  volume = {16},
  numero = {4},
  pages = {165 [14 p.]},
  year = {2024},
  DOI = {10.3390/toxins16040165},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090588},
}