@article{fdi:010090573,
  title = {{W}astewater sequencing as a powerful tool to reveal {SARS}-{C}o{V}-2 variant introduction and spread in {F}rench {G}uiana, {S}outh {A}merica},
  author = {{C}ombe, {M}arine and {C}herif, {E}mira and {D}eremarque, {T}. and {R}ivera-{I}ngraham, {G}. and {S}eck-{T}hiam, {F}. and {J}usty, {F}. and {D}oudou, {J}ean-{C}laude and {C}arod, {J}. {F}. and {C}arage, {T}. and {P}rocureur, {A}. and {G}ozlan, {R}odolphe},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he origin of introduction of a new pathogen in a country, the evolutionary dynamics of an epidemic within a country, and the role of cross -border areas on pathogen dynamics remain complex to disentangle and are often poorly understood. {F}or instance, cross -border areas represent the ideal location for the sharing of viral variants between countries, with international air travel, land travel and waterways playing an important role in the cross -border spread of infectious diseases. {U}nfortunately, monitoring the point of entry and the evolutionary dynamics of viruses in space and time within local populations remain challenging. {H}ere we tested the efficiency of wastewater -based epidemiology and genotyping in monitoring {C}ovid-19 epidemiology and {SARS}-{C}o{V}-2 variant dynamics in {F}rench {G}uiana, a tropical country located in {S}outh {A}merica. {O}ur results suggest that wastewater -based epidemiology and genotyping are powerful tools to monitor variant introduction and disease evolution within a tropical country but the inclusion of both clinical and wastewater samples could still improve our understanding of genetic diversity co -circulating. {W}astewater sequencing also revealed the cryptic transmission of {SARS}-{C}o{V}-2 variants within the country. {I}nterestingly, we found some amino acid changes specific to the variants co -circulating in {F}rench {G}uiana, suggesting a local evolution of the {SARS}-{C}o{V}-2 variants after their introduction. {M}ore importantly, our results showed that the proximity to bordering countries was not the origin of the emergence of the {F}rench {G}uianese {B}.1.160.25 variant, but rather that this variant emerged from an ancestor {B}.1.160 variant introduced by {E}uropean air plane travelers, suggesting thus that air travel remains a significant risk for cross -border spread of infectious diseases. {O}verall, we suggest that wastewater -based epidemiology and genotyping provides a cost effective and non-invasive approach for pathogen monitoring and an early -warning tool for disease emergence and spread within a tropical country.},
  keywords = {{V}irus ; {V}ariant emergence ; {C}ross-border effects ; {I}n-flight travel ; {GUYANE} {FRANCAISE}},
  booktitle = {},
  journal = {{S}cience of the {T}otal {E}nvironment},
  volume = {924},
  numero = {},
  pages = {171645 [15 p.]},
  ISSN = {0048-9697},
  year = {2024},
  DOI = {10.1016/j.scitotenv.2024.171645},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090573},
}