@article{fdi:010090560,
  title = {{W}hole-genome sequence and resistance determinants of four {E}lizabethkingia anophelis clinical isolates collected in {H}anoi, {V}ietnam},
  author = {{C}ommans, {F}lorian and {H}ayer, {J}uliette and {D}o, {B}. {N}. and {T}ran, {T}. {T}. {T}. and {L}e, {T}. {T}. {H}. and {B}ui, {T}. {T}. and {L}e, {H}. {S}. and {B}anuls, {A}nne-{L}aure and {B}ui, {T}. {S}. and {N}guyen, {Q}. {H}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}our isolates of the opportunistic pathogen {E}lizabethkingia anophelis were identified for the first time in a {V}ietnamese hospital and underwent antimicrobial susceptibility testing and genomic characterization by whole-genome sequencing. {C}omplete, fully circularized genome sequences were obtained for all four isolates. {A}verage {N}ucleotide {I}dentity analysis and single nucleotide polymorphism phylogenetic analysis on the core genome showed that three of the four isolates were genetically distinct, ruling out the hypothesis of a single strain emergence. {A}ntibiotic susceptibility testing highlighted multi-resistant phenotypes against most antimicrobial families, including beta-lactams, carbapenems, aminoglycosides, quinolones, macrolides, amphenicols, rifamycins and glycopeptides. {A}dditionally, in silico genomic analysis was used to correlate the phenotypic susceptibility to putative resistance determinants, including resistance genes, point mutations and multidrug efflux pumps. {N}ine different resistance genes were located inside a single resistance pocket predicted to be a putative {I}ntegrative and {C}onjugative {E}lement ({ICE}). {T}his novel {ICE} was shared by three isolates from two different lineages and displayed similarity with {ICE}s previously reported in various {E}lizabethkingia and {C}hryseobacterium species. {T}he role of such {ICE}s in pathogenicity, genome plasticity and antimicrobial resistance gene spread within the {F}lavobacteriaceae family needs to be further elucidated.},
  keywords = {{VIET} {NAM}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {14},
  numero = {1},
  pages = {7241 [16 p.]},
  ISSN = {2045-2322},
  year = {2024},
  DOI = {10.1038/s41598-024-57564-3},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090560},
}