@article{fdi:010090521,
  title = {{G}enomic insights into anthropozoonotic tuberculosis in captive sun bears ({H}elarctos malayanus) and an {A}siatic black bear ({U}rsus thibetanus) in {C}ambodia},
  author = {{O}fficer, {K}. and {W}alker, {T}. {M}. and {C}heng, {S}. {K}. and {H}eng, {S}. {H}. and {H}id{\'e}, {M}. and {B}anuls, {A}nne-{L}aure and {C}racknell, {J}. and {B}roadis, {N}. and {T}hy, {N}. and {A}braham, {S}. and {W}arren, {K}. and {J}ackson, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}ontact between humans and wildlife presents a risk for both zoonotic and anthropozoonotic disease transmission. {I}n this study we report the detection of human strains of {M}ycobacterium tuberculosis in sun bears and an {A}siatic black bear in a wildlife rescue centre in {C}ambodia, confirming for the first time the susceptibility of these bear species to tuberculosis when in close contact with humans. {A}fter genotyping revealed two different strains of {M}. tuberculosis from cases occurring between 2009 and 2019, 100 isolates from 30 sun bear cases, a single {A}siatic black bear case, and a human case were subjected to whole genome sequencing. {W}e combined single nucleotide polymorphism analysis and exploration of mixed base calls with epidemiological data to indicate the evolution of each outbreak. {O}ur results confirmed two concurrent yet separate tuberculosis outbreaks and established a likely transmission route in one outbreak where the human case acted as an intermediatory between bear cases. {I}n both outbreaks, we observed high rates of transmission and progression to active disease, suggesting that sun bears are highly susceptible to tuberculosis if exposed under these conditions. {O}verall, our findings highlight the risk of bi-directional transmission of tuberculosis between humans and captive bears in high human tuberculosis burden regions, with implied considerations for veterinary and public health. {W}e also demonstrate the use of standard genomic approaches to better understand disease outbreaks in captive wildlife settings and to inform control and prevention measures.},
  keywords = {{CAMBODGE}},
  booktitle = {},
  journal = {{S}cientific {R}eports- {N}ature},
  volume = {14},
  numero = {1},
  pages = {7343 [12 p.]},
  ISSN = {2045-2322},
  year = {2024},
  DOI = {10.1038/s41598-024-57318-1},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090521},
}