@article{fdi:010090517,
  title = {{E}xtensive variation and strain-specificity in dengue virus susceptibility among {A}frican {A}edes aegypti populations},
  author = {{D}abo, {S}. and {H}enrion-{L}acritick, {A}. and {L}ecuyer, {A}. and {J}iolle, {D}. and {P}aupy, {C}hristophe and {A}yala, {D}iego and {L}eal, {S}. {D}. and {B}adolo, {A}. and {V}ega-{R}úa, {A}. and {S}ylla, {M}. and {A}korli, {J}. and {O}too, {S}. and {L}utomiah, {J}. and {S}ang, {R}. and {M}utebi, {J}. {P}. and {S}aleh, {M}. {C}. and {R}ose, {N}. {H}. and {M}c{B}ride, {C}. {S}. and {L}ambrechts, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}frican populations of the mosquito {A}edes aegypti are usually considered less susceptible to infection by human-pathogenic flaviviruses than globally invasive populations found outside {A}frica. {A}lthough this contrast has been well documented for {Z}ika virus ({ZIKV}), it is unclear to what extent it is true for dengue virus ({DENV}), the most prevalent flavivirus of humans. {A}ddressing this question is complicated by substantial genetic diversity among {DENV} strains, most notably in the form of four genetic types ({DENV}1 to {DENV}4), that can lead to genetically specific interactions with mosquito populations. {H}ere, we carried out a survey of {DENV} susceptibility using a panel of seven field-derived {A}e. aegypti colonies from across the {A}frican range of the species and a colony from {G}uadeloupe, {F}rench {W}est {I}ndies as non-{A}frican reference. {W}e found considerable variation in the ability of {A}frican {A}e. aegypti populations to acquire and replicate a panel of six {DENV} strains spanning the four {DENV} types. {A}lthough {A}frican {A}e. aegypti populations were generally less susceptible than the reference non-{A}frican population from {G}uadeloupe, in several instances some {A}frican populations were equally or more susceptible than the {G}uadeloupe population. {M}oreover, the relative level of susceptibility between {A}frican mosquito populations depended on the {DENV} strain, indicating genetically specific interactions. {W}e conclude that unlike {ZIKV} susceptibility, there is no clear-cut dichotomy in {DENV} susceptibility between {A}frican and non-{A}frican {A}e. aegypti. {DENV} susceptibility of {A}frican {A}e. aegypti populations is highly heterogeneous and largely governed by the specific pairing of mosquito population and {DENV} strain.},
  keywords = {{KENYA} ; {OUGANDA} ; {GABON} ; {GHANA} ; {SENEGAL} ; {BURKINA} {FASO} ; {CAP} {VERT} ; {GUADELOUPE}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {18},
  numero = {3},
  pages = {e0011862 [14 p.]},
  ISSN = {1935-2735},
  year = {2024},
  DOI = {10.1371/journal.pntd.0011862},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090517},
}