@article{fdi:010090262,
  title = {{I}nsight into the role of phytoalexin naringenin and phytohormone abscisic acid in defense against phytopathogens {P}hytophthora infestans and {M}agnaporthe oryzae : {I}n vitro and in silico approaches},
  author = {{N}guyen-{N}goc, {H}. and {N}guyen, {C}. {Q}. and {V}o, {K}. {A}. {T}. and {N}guyen, {T}. {T}. {T}. and {N}ghiem, {D}. {T}. and {H}a, {N}. {T}. and {N}guyen, {V}. and {C}hoi, {G}. {J}. and {A}rdiansyah, {A}. {G}. and {N}guyen, {C}ong {T}hanh and {V}u, {H}. {D}. and {N}guyen, {N}. {T}. and {D}e {T}ran, {Q}. and {L}e {D}ang, {Q}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}hytoalexin naringenin and phytohormone abscisic acid ({ABA}) play crucial roles in plant defense and physiology. {T}his work encompassed both experimental and computational approaches to assess their antifungal efficacy against {P}hytophthora infestans and {M}agnaporthe oryzae. {N}aringenin and {ABA}, isolated from {D}esmodium sequax, exhibited significant in vitro antifungal activity against both pathogens. {N}aringenin was moderately active against {M}. oryzae in a dose-dependent manner, while {ABA} was not. {T}he antifungal efficacy of {ABA} against {P}. infestans ({IC}50 = 19.7 mu g/m{L} and {IC}90 = 72.0 mu g/m{L}) was more potent when compared with that of naringenin ({IC}50 = 53.7 mu g/m{L} and {IC}90 = 129.2 mu g/m{L}). {C}omputational models provided insights into their interactions with pathogenic enzymes. {N}aringenin emerged as a novel inhibitor of {M}. oryzae enzymes (1,3,8-trihydroxynaphthalene reductase and scytalone dehydratase); and together with {ABA}, it exhibited robust interactions with targeted {P}. infestans enzymes (chitin synthase and calmodulin). {L}igand-based pharmacophore models were constructed for prospective {P}. infestans inhibitors. {T}hese findings highlight the mechanism and antifungal potential of naringenin and {ABA} and suggest their use as natural fungicides in sustainable agriculture.},
  keywords = {{N}aringenin ; {A}bscisic acid ; {A}ntifungal defense ; {P}hytophthora infestans ; {M}agnaporthe oryzae},
  booktitle = {},
  journal = {{P}hysiological and {M}olecular {P}lant {P}athology},
  volume = {127},
  numero = {},
  pages = {102123 [11 p.]},
  ISSN = {0885-5765},
  year = {2023},
  DOI = {10.1016/j.pmpp.2023.102123},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090262},
}