@article{fdi:010090228,
  title = {{G}enome editing of an {A}frican elite rice variety confers resistance against endemic and emerging {X}anthomonas oryzae pv. oryzae strains},
  author = {{S}chepler-{L}uu, {V}. and {S}ciallano, {C}. and {S}tiebner, {M}. and {J}i, {C}. {H}. and {B}oulard, {G}abriel and {D}iallo, {A}. and {A}uguy, {F}lorence and {C}har, {S}. {N}. and {A}rra, {Y}. and {S}chenstnyi, {K}. and {B}uchholzer, {M}. and {L}oo, {E}. {P}. {I}. and {B}ilaro, {A}. {L}. and {L}ihepanyama, {D}. and {M}kuya, {M}. and {M}urori, {R}. and {O}liva, {R}. and {C}unnac, {S}{\'e}bastien and {Y}ang, {B}. and {S}zurek, {B}oris and {F}rommer, {W}. {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}acterial leaf blight ({BB}) of rice, caused by {X}anthomonas oryzae pv. oryzae ({X}oo), threatens global food security and the livelihood of small-scale rice producers. {A}nalyses of {X}oo collections from {A}sia, {A}frica and the {A}mericas demonstrated complete continental segregation, despite robust global rice trade. {H}ere, we report unprecedented {BB} outbreaks in {T}anzania. {T}he causative strains, unlike endemic {A}frican {X}oo, carry {A}sian-type {TAL} effectors targeting the sucrose transporter {SWEET}11a and i{TAL}es suppressing {X}a1. {P}hylogenomics clustered these strains with {X}oo from {S}outhern-{C}hina. {A}frican rice varieties do not carry effective resistance. {T}o protect {A}frican rice production against this emerging threat, we developed a hybrid {CRISPR}-{C}as9/{C}pf1 system to edit all known {TAL}e-binding elements in three {SWEET} promoters of the {E}ast {A}frican elite variety {K}omboka. {T}he edited lines show broad-spectrum resistance against {A}sian and {A}frican strains of {X}oo, including strains recently discovered in {T}anzania. {T}he strategy could help to protect global rice crops from {BB} pandemics.},
  keywords = {{O}ryza sativa ; {X}anthomonas oryzae pv oryzae ; {A}grobacterium tumefaciens ; pathogen ; {TANZANIE}},
  booktitle = {},
  journal = {e{L}ife},
  volume = {12},
  numero = {},
  pages = {e84864 [26 p.]},
  ISSN = {2050-084{X}},
  year = {2023},
  DOI = {10.7554/e{L}ife.84864},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090228},
}