%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Fall, Akdj
%A Dechavanne, Célia
%A Sabbagh, A.
%A Garcia, André
%A Courtin, David
%A Migot Nabias, Florence
%T Combined polymorphisms involving the IgG heavy chain and Fc gamma receptors among Fulani and non-Fulani in Benin : implications for the natural protection of young Fulani against Plasmodium falciparum malaria infections
%D 2023
%L fdi:010090200
%G ENG
%J Infection Genetics and Evolution
%@ 1567-1348
%K G3m6 allotype ; Fc & gamma ; Rs ; Malaria ; Fulani ; Benin
%K BENIN
%M ISI:001059224800001
%P 105461 [11 ]
%R 10.1016/j.meegid.2023.105461
%U https://www.documentation.ird.fr/hor/fdi:010090200
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2023-10/010090200.pdf
%V 112
%W Horizon (IRD)
%X A decreased susceptibility of Fulani populations to malaria infections has been shown in Africa. A previous longitudinal cohort study conducted in the Atacora region of northern Benin showed a high merozoite-phagocytosis capacity in young Fulani. Here, we explored the combined polymorphisms in the constant region of the IgG3 heavy chain (presence/absence of the G3m6 allotype) and in Fc gamma receptors (Fc?Rs) as potentially involved in the natural protection against malaria of young Fulani in Benin. An active malaria follow-up was conducted among individuals from Fulani, Bariba, Otamari and Gando ethnic groups living in sympatry in Atacora, over the full malaria transmission season. Fc?RIIA 131R/H (rs1801274), Fc?RIIC C/T (rs3933769) and Fc?RIIIA 176F/V (rs396991) were determined using the TaqMan method; Fc?RIIIB NA1/NA2 was assessed by polymerase chain reaction (PCR) using allele-specific primers and G3m6 using allotype by PCR-RFLP. Individual carriage of G3m6 (+) was associated with an increased risk of Pf malaria infection (logistic multivariate regression model (lmrm), OR = 2.25, 95% CI = 1.06;4.74, P = 0.034). Combined haplotype G3m6 (+) - Fc?RIIA 131H - Fc?RIIC T - Fc?RIIIA 176F - Fc?RIIIB NA2 was also associated with an increased risk of Pf malaria infection (lmrm, OR = 13.01, 95% CI = 1.69;99.76, P = 0.014). G3m6 (?), Fc?RIIA 131R and Fc?RIIIB NA1 were more prevalent in young Fulani (P = 0.002, P < 0.001 and P = 0.049, respectively), while no Fulani presented the combined G3m6 (+) - Fc?RIIA 131H - Fc?RIIC T - Fc?RIIIA 176F - Fc?RIIIB NA2 haplotype that was carried by a majority of infected children. Our results highlight the combined factors G3m6 - Fc?R as potentially involved in the merozoite-phagocytosis capacity and in the natural protection of young Fulani individuals against P. falciparum malaria in Benin.
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