@article{fdi:010090200,
  title = {{C}ombined polymorphisms involving the {I}g{G} heavy chain and {F}c gamma receptors among {F}ulani and non-{F}ulani in {B}enin : implications for the natural protection of young {F}ulani against {P}lasmodium falciparum malaria infections},
  author = {{F}all, {A}kdj and {D}echavanne, {C}{\'e}lia and {S}abbagh, {A}. and {G}arcia, {A}ndr{\'e} and {C}ourtin, {D}avid and {M}igot {N}abias, {F}lorence},
  editor = {},
  language = {{ENG}},
  abstract = {{A} decreased susceptibility of {F}ulani populations to malaria infections has been shown in {A}frica. {A} previous longitudinal cohort study conducted in the {A}tacora region of northern {B}enin showed a high merozoite-phagocytosis capacity in young {F}ulani. {H}ere, we explored the combined polymorphisms in the constant region of the {I}g{G}3 heavy chain (presence/absence of the {G}3m6 allotype) and in {F}c gamma receptors ({F}c?{R}s) as potentially involved in the natural protection against malaria of young {F}ulani in {B}enin. {A}n active malaria follow-up was conducted among individuals from {F}ulani, {B}ariba, {O}tamari and {G}ando ethnic groups living in sympatry in {A}tacora, over the full malaria transmission season. {F}c?{RIIA} 131{R}/{H} (rs1801274), {F}c?{RIIC} {C}/{T} (rs3933769) and {F}c?{RIIIA} 176{F}/{V} (rs396991) were determined using the {T}aq{M}an method; {F}c?{RIIIB} {NA}1/{NA}2 was assessed by polymerase chain reaction ({PCR}) using allele-specific primers and {G}3m6 using allotype by {PCR}-{RFLP}. {I}ndividual carriage of {G}3m6 (+) was associated with an increased risk of {P}f malaria infection (logistic multivariate regression model (lmrm), {OR} = 2.25, 95% {CI} = 1.06;4.74, {P} = 0.034). {C}ombined haplotype {G}3m6 (+) - {F}c?{RIIA} 131{H} - {F}c?{RIIC} {T} - {F}c?{RIIIA} 176{F} - {F}c?{RIIIB} {NA}2 was also associated with an increased risk of {P}f malaria infection (lmrm, {OR} = 13.01, 95% {CI} = 1.69;99.76, {P} = 0.014). {G}3m6 (?), {F}c?{RIIA} 131{R} and {F}c?{RIIIB} {NA}1 were more prevalent in young {F}ulani ({P} = 0.002, {P} < 0.001 and {P} = 0.049, respectively), while no {F}ulani presented the combined {G}3m6 (+) - {F}c?{RIIA} 131{H} - {F}c?{RIIC} {T} - {F}c?{RIIIA} 176{F} - {F}c?{RIIIB} {NA}2 haplotype that was carried by a majority of infected children. {O}ur results highlight the combined factors {G}3m6 - {F}c?{R} as potentially involved in the merozoite-phagocytosis capacity and in the natural protection of young {F}ulani individuals against {P}. falciparum malaria in {B}enin.},
  keywords = {{G}3m6 allotype ; {F}c & gamma ; {R}s ; {M}alaria ; {F}ulani ; {B}enin ; {BENIN}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {112},
  numero = {},
  pages = {105461 [11 p.]},
  ISSN = {1567-1348},
  year = {2023},
  DOI = {10.1016/j.meegid.2023.105461},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090200},
}