@article{fdi:010090139,
  title = {{T}arget product profile : diagnostic test for {T}rypanosoma brucei rhodesiense},
  author = {{P}riotto, {G}. and {F}ranco, {J}. {R}. and {L}ejon, {V}eerle and {B}uescher, {P}. and {M}atovu, {E}. and {N}dung'u, {J}. and {B}ieler, {S}. and {M}umba, {D}. and {V}an {R}eet, {N}. and {V}erle, {P}. and {J}amonneau, {V}incent and {S}imarro, {P}. {P}. and {E}beja, {A}. {K}. and {S}ankara, {D}. and {D}agne, {D}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{R}hodesiense human {A}frican trypanosomiasis is a lethal parasitic infection caused by {T}rypanosoma brucei rhodesiense and transmitted by tsetse flies in eastern and southern {A}frica. {I}t accounts for around 5% of all cases of human {A}frican trypanosomiasis. {C}urrently, there is no simple serological test for rhodesiense human {A}frican trypanosomiasis and diagnosis relies on microscopic confirmation of trypanosomes in samples of blood or other tissues. {T}he availability of a simple and accurate diagnostic test would aid the control, surveillance and treatment of the disease. {A} subcommittee of the {W}orld {H}ealth {O}rganization's {N}eglected {T}ropical {D}iseases {D}iagnostics {T}echnical {A}dvisory {G}roup has developed a target product profile for a diagnostic tool to identify {T}. b. rhodesiense infection. {T}he optimum tool would have a sensitivity and specificity above 99% for detecting {T}. b. rhodesiense, but be simple enough for use by minimally trained health-care workers in unsophisticated peripheral health facilities or mobile teams in villages. {T}he test should yield a qualitative result that can be easily observed and can be used to determine treatment. {A}n antigen test would be preferable, with blood collected by finger-prick. {I}deally, there should be no need for a cold chain, instrumentation or precision liquid handling. {T}he test should be usable between 10 °{C} and 40 °{C} and between 10% and 88% relative humidity. {B}asic training should take under 2 hours and the test should involve fewer than five steps. {T}he unit cost should be less than 1 {U}nited {S}tates dollar.},
  keywords = {{AFRIQUE} {DE} {L}'{EST} ; {AFRIQUE} {DU} {SUD}},
  booktitle = {},
  journal = {{B}ulletin of the {W}orld {H}ealth {O}rganization},
  volume = {101},
  numero = {8},
  pages = {529--534},
  ISSN = {0042-9686},
  year = {2023},
  DOI = {10.2471/blt.23.290173},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090139},
}