@article{fdi:010090096,
  title = {{M}alaria infections and placental blood flow : a doppler ultrasound study from a preconception cohort in {B}enin},
  author = {{M}ondeilh, {A}. and {Y}ovo, {E}. and {A}ccrombessi, {M}. and {H}ounkonnou, {C}. and {A}gbota, {G}ino and {A}tade, {W}. and {L}adikpo, {O}. {T}. and {M}ehoba, {M}. and {D}egbe, {A}. and {V}ianou, {B}. and {S}ossou, {D}. and {T}uikue {N}dam, {N}icaise and {M}assougbodji, {A}. and {M}c{G}ready, {R}. and {F}ievet, {N}adine and {R}ijken, {M}. {J}. and {C}ottrell, {G}illes and {B}riand, {V}al{\'e}rie},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {M}alaria in pregnancy ({M}i{P}) has been associated with fetal growth restriction, the underlying pathogenic mechanisms of which remain poorly understood. {M}alaria in pregnancy is suspected to induce abnormalities in placental vascularization, leading to impaired placental development. {O}ur study evaluated {MIP}'s effect on uterine artery ({U}t{A}) and umbilical artery ({UA}) blood flow. {M}ethods {T}he analysis included 253 {B}eninese women followed throughout pregnancy and screened monthly for submicroscopic and microscopic malaria. {U}terine artery {D}oppler measurement was performed once between 21 and 25 weeks' gestation (wg), and {UA} {D}oppler measurement was performed 1-3 times from 28 wg. {L}inear and logistic regression models were used to assess the effect of malaria infections on {U}t{A} {D}oppler indicators (pulsatility index and presence of a notch), whereas a logistic mixed model was used to assess the association between malaria infections and abnormal {UA} {D}oppler (defined as {Z}-score & {GE};2 standard deviation or absent/reversed {UA} end-diastolic flow). {R}esults {P}rimigravidae represented 7.5% of the study population; 42.3% of women had at least 1 microscopic infection during pregnancy, and 29.6% had at least 1 submicroscopic infection (and no microscopic infection). {B}oth microscopic and submicroscopic infections before {D}oppler measurement were associated with the presence of a notch (adjusted odds ratio [a{OR}] 4.5, 95% confidence interval [{CI}] = 1.2-16.3 and a{OR} 3.3, 95% {CI} = .9-11.9, respectively). {N}o associations were found between malaria before the {D}oppler measurement and abnormal {UA} {D}oppler. {C}onclusions {M}alaria infections in the first half of pregnancy impair placental blood flow. {T}his highlights the need to prevent malaria from the very beginning of pregnancy.},
  keywords = {{A}frica ; {D}oppler measurements ; malaria in pregnancy ; umbilical artery ; uterine artery ; {BENIN}},
  booktitle = {},
  journal = {{O}pen {F}orum {I}nfectious {D}iseases},
  volume = {10},
  numero = {8},
  pages = {ofad376 [9 p.]},
  ISSN = {2328-8957},
  year = {2023},
  DOI = {10.1093/ofid/ofad376},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090096},
}