@article{fdi:010090095,
  title = {{E}xcess mortality associated with {L}oiasis : confirmation by a new retrospective cohort study conducted in the {R}epublic of {C}ongo},
  author = {{H}emilembolo, {M}. {C}. and {N}iama, {A}. {C}. and {C}ampillo, {J}{\'e}r{\'e}my and {P}ion, {S}{\'e}bastien and {M}issamou, {F}. and {W}hittaker, {C}. and {K}ankou, {J}. {M}. and {N}dziessi, {G}. and {B}ileckot, {R}. {R}. and {B}oussinesq, {M}ichel and {C}hesnais, {C}{\'e}dric},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {L}oiasis ({L}oa loa filariasis) is considered a benign disease and is currently not included in the {W}orld {H}ealth {O}rganization's ({WHO}'s) list of {N}eglected {T}ropical {D}iseases, despite mounting evidence suggesting significant disease burden in endemic areas. {W}e conducted a retrospective cohort study to assess the mortality associated with {L}. loa microfilaremia in the {S}outhwestern {R}epublic of {C}ongo. {M}ethods {T}he cohort included 3329 individuals from 53 villages screened for loiasis in 2004. {W}e compared mortality rates in 2021 for individuals initially diagnosed as with or without {L}. loa microfilariae 17 years earlier. {D}ata were analyzed at the community level to calculate crude mortality rates. {S}urvival models were used to estimate the effect of {L}. loa microfilaremia on mortality in the population. {R}esults {A}t baseline, prevalence of microfilaremia was 16.2%. {D}uring 17.62 years of cohort follow-up, 751 deaths were recorded, representing a crude mortality rate of 15.36 (95% {CI}, 14.28-16.50) per 1000 person-years. {M}edian survival time was 58.5 (95% {CI}, 49.7-67.3) years and 39.2 (95% {CI}, 32.6-45.8) years for amicrofilaremic and microfilaremic indiviudals, respectively. {C}onclusions {A} significant reduction in life expectancy was associated with {L}. loa microfilaremia, confirming previous observations from {C}ameroon. {T}his adds to the evidence that loiasis is not a benign disease and deserves to be included in the {WHO}'s list of {N}eglected {T}ropical {D}iseases.},
  keywords = {loiasis ; {R}epublic of {C}ongo ; cohort study ; filariasis ; mortality ; {CONGO}},
  booktitle = {},
  journal = {{O}pen {F}orum {I}nfectious {D}iseases},
  volume = {10},
  numero = {3},
  pages = {[8 p.]},
  ISSN = {2328-8957},
  year = {2023},
  DOI = {10.1093/ofid/ofad103},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090095},
}