@article{fdi:010089763,
  title = {{T}he amnesic shellfish poisoning toxin, domoic acid : the tattoo of the king scallop {P}ecten maximus},
  author = {{G}arcía-{C}orona, {J}. {L}. and {F}abioux, {C}. and {V}anmaldergem, {J}. and {P}etek, {S}ylvain and {D}errien, {A}. and {T}erre-{T}errillon, {A}. and {B}ressolier, {L}. and {B}reton, {F}. and {H}egaret, {H}.},
  editor = {},
  language = {{ENG}},
  abstract = {{D}omoic acid ({DA}) is a potent neurotoxin produced by diatoms of the genus {P}seudo-nitzschia and is responsible for {A}mnesic {S}hellfish {P}oisoning ({ASP}) in humans. {S}ome fishery resources of high commercial value, such as the king scallop {P}ecten maximus, are frequently exposed to toxic {P}seudo-nitzschia blooms and are capable of accumulating high amounts of {DA}, retaining it for months or even a few years. {T}his poses a serious threat to public health and a continuous economical risk due to fishing closures of this resource in the affected areas. {R}ecently, it was hypothesized that trapping of {DA} within autophagosomic-vesicles could be one reason explaining the long retention of the remaining toxin in {P}. maximus digestive gland. {T}o test this idea, we follow the kinetics of the subcellular localization of {DA} in the digestive glands of {P}. maximus during (a) the contamination process - with sequential samplings of scallops reared in the field during 234 days and naturally exposed to blooms of {DA}-producing {P}seudo-nitzschia australis, and (b) the decontamination process - where highly contaminated scallops were collected after a natural bloom of toxic {P}. australis and subjected to {DA}-depuration in the laboratory for 60 days. {I}n the digestive gland, {DA}-depuration rate (0.001 day(-1)) was much slower than contamination kinetics. {T}he subcellular analyses revealed a direct implication of early autophagy in {DA} sequestration throughout contamination (r = 0.8, {P} < 0.05), while the presence of {DA}-labeled residual bodies (late autophagy) appeared to be strongly and significantly related to slow {DA}-depuration (r = -0.5) resembling an analogous {DA}-tattooing in the digestive glands of {P}. maximus. {T}his work provides new evidence about the potential physiological mechanisms involved in the long retention of {DA} in {P}. maximus and represents the baseline to explore procedures to accelerate decontamination in this species.},
  keywords = {{D}omoic acid ; {P}ecten maximus ; {T}oxicokinetics ; {R}apid accumulation ; {S}low depuration ; {A}utophagy ; {FRANCE} ; {BRETAGNE}},
  booktitle = {},
  journal = {{H}armful {A}lgae},
  volume = {133},
  numero = {},
  pages = {102607 [11 ]},
  ISSN = {1568-9883},
  year = {2024},
  DOI = {10.1016/j.hal.2024.102607},
  URL = {https://www.documentation.ird.fr/hor/fdi:010089763},
}