@article{fdi:010089711,
  title = {{E}vidence for circulation of {R}ift {V}alley fever virus in wildlife and domestic animals in a forest environment in {G}abon, {C}entral {A}frica},
  author = {{B}ecquart, {P}ierre and {K}ombila, {L}. {B}. and {M}ebaley, {T}. {N}. and {P}aupy, {C}hristophe and {G}arcia, {D}. and {N}esi, {N}. and {O}live, {M}. {M}. and {V}anhomwegen, {J}. and {B}oundenga, {L}. and {M}ombo, {I}. {M}. and {P}iro-{M}egy, {C}. and {F}ritz, {M}atthieu and {L}enguiya, {L}. {H}. and {G}ouilh, {M}. {A}. and {L}eroy, {E}ric and {N}'{D}ilimabaka, {N}. and {C}etre-{S}ossah, {C}. and {M}aganga, {G}. {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{R}ift {V}alley fever ({RVF}) is a mosquito-borne viral zoonosis caused by the {R}ift {V}alley fever virus ({RVFV}) that can infect domestic and wild animals. {A}lthough the {RVFV} transmission cycle has been well documented across {A}frica in savanna ecosystems, little is known about its transmission in tropical rainforest settings, particularly in {C}entral {A}frica. {W}e therefore conducted a survey in northeastern {G}abon to assess {RVFV} circulation among wild and domestic animals. {A}mong 163 wildlife samples tested using {RVFV}-specific {RT}-q{PCR}, four ruminants belonging to subfamily {C}ephalophinae were detected positive. {T}he phylogenetic analysis revealed that the four {RVFV} sequences clustered together with a virus isolated in {N}amibia within the well-structured {E}gyptian clade. {A} cross-sectional survey conducted on sheep, goats and dogs living in villages within the same area determined the {I}g{G} {RVFV}-specific antibody prevalence using c{ELISA}. {O}ut of the 306 small ruminants tested (214 goats, 92 sheep), an overall antibody prevalence of 15.4% (95% {CI} [11.5-19.9]) was observed with a higher rate in goats than in sheep (20.1% versus 3.3%). {RVFV}-specific antibodies were detected in a single dog out of the 26 tested. {N}either age, sex of domestic animals nor season was found to be significant risk factors of {RVFV} occurrence. {O}ur findings highlight sylvatic circulation of {RVFV} for the first time in {G}abon. {T}hese results stress the need to develop adequate surveillance plan measures to better control the public health threat of {RVFV}. {R}ift {V}alley fever ({RVF}) is a mosquito-borne viral zoonosis caused by the {R}ift {V}alley fever virus ({RVFV}) that can affect wild and domestic animals. {A}lthough the {RVFV} transmission cycle has been well documented across {A}frica in savanna ecosystems, little is known about its transmission in tropical rainforests, especially in {C}entral {A}frica. {W}e thus conducted a survey in northeastern {G}abon to assess {RVFV} circulation among wild and domestic animals. {I}n this study, we demonstrated for the first time in {G}abon the presence of the {RVFV} in two wildlife species ({P}eter's duiker {C}ephalophus callipygus and the blue duiker {P}hilantomba monticola). {I}n addition, we detected {RVFV}-specific antibodies in small domestic ruminants (sheep and goats) at an overall antibody prevalence of 15.4%, with a much higher seroprevalence rate in goats than sheep (20.1% versus 3.3%). {F}urthermore, {RVFV}-specific antibodies were also observed in a single (hunting) dog out of the 26 tested. {T}hese results stress the need to develop adequate surveillance plan measures to better control the public health threat of {RVFV}.},
  keywords = {{GABON}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {18},
  numero = {3},
  pages = {e0011756 [15 ]},
  ISSN = {1935-2735},
  year = {2024},
  DOI = {10.1371/journal.pntd.0011756},
  URL = {https://www.documentation.ird.fr/hor/fdi:010089711},
}