@article{fdi:010089652,
  title = {{IL}-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine {T}rypanosoma brucei infection [+ {C}orrection, vol. 15, 1833, 2024]},
  author = {{S}inton, {M}. {C}. and {C}handrasegaran, {P}. {R}. {G}. and {C}apewell, {P}. and {C}ooper, {A}. and {G}irard, {A}. and {O}gunsola, {J}. and {P}erona-{W}right, {G}. and {N}goyi, {D}. and {K}uispond, {N}. and {B}ucheton, {B}runo and {C}amara, {M}. and {K}ajimura, {S}. and {B}{\'e}n{\'e}zech, {C}. and {M}abbott, {N}. {A}. and {M}ac{L}eod, {A}. and {Q}uintana, {J}. {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n the skin, {T}rypanosoma brucei colonises the subcutaneous white adipose tissue, and is proposed to be competent for forward transmission. {T}he interaction between parasites, adipose tissue, and the local immune system is likely to drive the adipose tissue wasting and weight loss observed in cattle and humans infected with {T}. brucei. {H}owever, mechanistically, events leading to subcutaneous white adipose tissue wasting are not fully understood. {H}ere, using several complementary approaches, including mass cytometry by time of flight, bulk and single cell transcriptomics, and in vivo genetic models, we show that {T}. brucei infection drives local expansion of several {IL}-17{A}-producing cells in the murine {WAT}, including {TH}17 and {V} gamma 6+ cells. {W}e also show that global {IL}-17 deficiency, or deletion of the adipocyte {IL}-17 receptor protect from infection-induced {WAT} wasting and weight loss. {U}nexpectedly, we find that abrogation of adipocyte {IL}-17 signalling results in a significant accumulation of {D}pp4+{P}i16+ interstitial preadipocytes and increased extravascular parasites in the {WAT}, highlighting a critical role for {IL}-17 signalling in controlling preadipocyte fate, subcutaneous {WAT} dynamics, and local parasite burden. {T}aken together, our study highlights the central role of adipocyte {IL}-17 signalling in controlling {WAT} responses to infection, suggesting that adipocytes are critical coordinators of tissue dynamics and immune responses to {T}. brucei infection.},
  keywords = {},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {14},
  numero = {1},
  pages = {7070 [21 ] [+ correction 1 p.]},
  year = {2023},
  DOI = {10.1038/s41467-023-42918-8},
  URL = {https://www.documentation.ird.fr/hor/fdi:010089652},
}