@article{fdi:010089644,
  title = {{I}n vitro competition between two transmissible cancers and potential implications for their host, the {T}asmanian devil},
  author = {{G}{\'e}rard, {A}. {L}. and {O}wen, {R}. {S}. and {D}ujon, {A}. {M}. and {R}oche, {B}enjamin and {H}amede, {R}. and {T}homas, {F}. and {U}jvari, {B}. and {S}iddle, {H}. {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ince the emergence of a transmissible cancer, devil facial tumour disease ({DFT}1), in the 1980s, wild {T}asmanian devil populations have been in decline. {I}n 2016, a second, independently evolved transmissible cancer ({DFT}2) was discovered raising concerns for survival of the host species. {H}ere, we applied experimental and modelling frameworks to examine competition dynamics between the two transmissible cancers in vitro. {U}sing representative cell lines for {DFT}1 and {DFT}2, we have found that in monoculture, {DFT}2 grows twice as fast as {DFT}1 but reaches lower maximum cell densities. {U}sing co-cultures, we demonstrate that {DFT}2 outcompetes {DFT}1: the number of {DFT}1 cells decreasing over time, never reaching exponential growth. {T}his phenomenon could not be replicated when cells were grown separated by a semi-permeable membrane, consistent with exertion of mechanical stress on {DFT}1 cells by {DFT}2. {A} logistic model and a {L}otka-{V}olterra competition model were used to interrogate monoculture and co-culture growth curves, respectively, suggesting {DFT}2 is a better competitor than {DFT}1, but also showing that competition outcomes might depend on the initial number of cells, at least in the laboratory. {W}e provide theories how the in vitro results could be translated to observations in the wild and propose that these results may indicate that although {DFT}2 is currently in a smaller geographic area than {DFT}1, it could have the potential to outcompete {DFT}1. {F}urthermore, we provide a framework for improving the parameterization of epidemiological models applied to these cancer lineages, which will inform future disease management.},
  keywords = {competition model ; {L}otka-{V}olterra model ; {T}asmanian devil ; transmissible ; cancer ; {AUSTRALIE}},
  booktitle = {},
  journal = {{E}volutionary {A}pplications},
  volume = {17},
  numero = {3},
  pages = {e13670 [12 p.]},
  ISSN = {1752-4571},
  year = {2024},
  DOI = {10.1111/eva.13670},
  URL = {https://www.documentation.ird.fr/hor/fdi:010089644},
}