Marsal Anouk auteur aut IRD Slama R. auteur aut IRD Lyon-Caen S. auteur aut IRD Borlaza L. J. S. auteur aut IRD Jaffrezo J. L. auteur aut IRD Boudier A. auteur aut IRD Darfeuil Sophie auteur aut IRD Elazzouzi R. auteur aut IRD Gioria Y. auteur aut IRD Lepeule J. auteur aut IRD Chartier R. auteur aut IRD Pin I. auteur aut IRD Quentin J. auteur aut IRD Bayat S. auteur aut IRD Uzu Gaëlle auteur aut IRD Siroux V. auteur aut IRD text journalArticle eng text/pdf reformatted digital access BACKGROUND: Fine particulate matter (PM2.5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children.OBJECTIVES: We estimated the associations of personal exposure to PM2.5 and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics.METHODS: We used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N2MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM2.5 mass and OP with lung function parameters were estimated using multiple linear regressions.RESULTS: In neonates, an interquartile (IQR) increase in OPDTTv (0.89 nmol/min/m3) was associated with a decrease in functional residual capacity (FRC) measured byN2MBW [beta = - 2.26 mL; 95% confidence interval (CI): -4.68, 0.15]. Associations with PM2.5 showed similar patterns in comparison with OPDTT v but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs7-19) from AOS tended to be associated with higher OPDTT v (beta = 0.09 hPa x s/L; 95% CI: -0.06, 0.24) and OPAAv (IQR =1.14 nmol/min/m3; beta = 0.12 hPa x s/L; 95% CI: -0.04, 0.27) but not with PM2.5 (IQR = 6.9 mu g/m3; beta = 0.02 hPa x s/L; 95% CI: -0.13, 0.16). Results for FRC and Rrs7-19 remained similar in OP models adjusted on PM2.5.DISCUSSION: Prenatal exposure to OPDTT v was associated with several offspring lung function parameters over time, all related to lung volumes. specialized FRANCE 050 038 021 131 1 017004 [12 p.] 2023 0091-6765 https://www.documentation.ird.fr/hor/fdi:010089590 10.1289/ehp11155 0091-6765 [F B010089590] https://www.documentation.ird.fr/hor/fdi:010089590 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2024-04/010089590.pdf IRD - Base Horizon / Pleins textes 2024-04-05 2025-02-24 fdi:010089590 fre