@article{fdi:010089590,
  title = {{P}renatal exposure to {PM}2.5 oxidative potential and lung function in infants and preschool- age children : a prospective study},
  author = {{M}arsal, {A}nouk and {S}lama, {R}. and {L}yon-{C}aen, {S}. and {B}orlaza, {L}. {J}. {S}. and {J}affrezo, {J}. {L}. and {B}oudier, {A}. and {D}arfeuil, {S}ophie and {E}lazzouzi, {R}. and {G}ioria, {Y}. and {L}epeule, {J}. and {C}hartier, {R}. and {P}in, {I}. and {Q}uentin, {J}. and {B}ayat, {S}. and {U}zu, {G}a{\¨e}lle and {S}iroux, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{BACKGROUND}: {F}ine particulate matter ({PM}2.5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal {PM}2.5 oxidative potential ({OP}) on lung function in infants and preschool children.{OBJECTIVES}: {W}e estimated the associations of personal exposure to {PM}2.5 and {OP} during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics.{METHODS}: {W}e used data from 356 mother-child pairs from the {SEPAGES} cohort. {PM} filters collected twice during a week were analyzed for {OP}, using the dithiothreitol ({DTT}) and the ascorbic acid ({AA}) assays, quantifying the exposure of each pregnant woman. {L}ung function was assessed with tidal breathing analysis ({TBFVL}) and nitrogen multiple-breath washout ({N}2{MBW}) test, performed at 6 wk, and airwave oscillometry ({AOS}) performed at 3 y. {A}ssociations of prenatal {PM}2.5 mass and {OP} with lung function parameters were estimated using multiple linear regressions.{RESULTS}: {I}n neonates, an interquartile ({IQR}) increase in {OPDTT}v (0.89 nmol/min/m3) was associated with a decrease in functional residual capacity ({FRC}) measured by{N}2{MBW} [beta = - 2.26 m{L}; 95% confidence interval ({CI}): -4.68, 0.15]. {A}ssociations with {PM}2.5 showed similar patterns in comparison with {OPDTT} v but of smaller magnitude. {L}ung clearance index ({LCI}) and {TBFVL} parameters did not show any clear association with the exposures considered. {A}t 3 y, increased frequency-dependent resistance of the lungs ({R}rs7-19) from {AOS} tended to be associated with higher {OPDTT} v (beta = 0.09 h{P}a x s/{L}; 95% {CI}: -0.06, 0.24) and {OPAA}v ({IQR} =1.14 nmol/min/m3; beta = 0.12 h{P}a x s/{L}; 95% {CI}: -0.04, 0.27) but not with {PM}2.5 ({IQR} = 6.9 mu g/m3; beta = 0.02 h{P}a x s/{L}; 95% {CI}: -0.13, 0.16). {R}esults for {FRC} and {R}rs7-19 remained similar in {OP} models adjusted on {PM}2.5.{DISCUSSION}: {P}renatal exposure to {OPDTT} v was associated with several offspring lung function parameters over time, all related to lung volumes.},
  keywords = {{FRANCE}},
  booktitle = {},
  journal = {{E}nvironmental {H}ealth {P}erspectives},
  volume = {131},
  numero = {1},
  pages = {017004 [12 p.]},
  ISSN = {0091-6765},
  year = {2023},
  DOI = {10.1289/ehp11155},
  URL = {https://www.documentation.ird.fr/hor/fdi:010089590},
}