@article{fdi:010089539,
  title = {{A}ssessment of the performance of lactate dehydrogenase-based rapid diagnostic test for malaria in {D}jibouti in 2022-2023},
  author = {{M}oussa, {R}. {A}. and {M}ze, {N}. {P}. and {A}rreh, {H}. {Y}. and {H}amoud, {A}. {A}. and {A}laleh, {K}. {M}. and {A}den, {F}. {M}. and {O}mar, {A}. {R}. {Y}. and {A}bdi, {W}. {O}. and {G}uelleh, {S}. {K}. and {A}bdi, {A}. {I}. {A}. and {B}asco, {L}eonardo and {K}haireh, {B}. {A}. and {B}ogreau, {H}.},
  editor = {},
  language = {{ENG}},
  abstract = {{U}ntil 2020, {D}jiboutian health authorities relied on histidine-rich protein-2 ({HRP}2)-based rapid diagnostic tests ({RDT}s) to establish the diagnosis of {P}lasmodium falciparum. {T}he rapid spread of {P}. falciparum histidine-rich protein-2 and -3 (pfhrp2/3) gene-deleted parasite strains in {D}jibouti has led the authorities to switch from {HRP}2-based {RDT}s to lactate dehydrogenase ({LDH})-based {RDT}s targeting the plasmodial lactate dehydrogenase (p{LDH}) specific for {P}. falciparum and {P}. vivax ({R}api{GEN} {BIOCREDIT} {M}alaria {A}g {P}f/{P}v p{LDH}/p{LDH}) in 2021. {T}his study was conducted with the primary objective of evaluating the diagnostic performance of this alternative {RDT}. {O}perational constraints related, in particular, to the implementation of this {RDT} during the {COVID}-19 pandemic were also considered. {T}he performance of {BIOCREDIT} {M}alaria {A}g {P}f/{P}v (p{LDH}/p{LDH}) {RDT} was also compared to our previously published data on the performance of two {HRP}2-based {RDT}s deployed in {D}jibouti in 2018-2020. {T}he diagnosis of 350 febrile patients with suspected malaria in {D}jibouti city was established using two batches of {R}api{GEN} {BIOCREDIT} {M}alaria {A}g {P}f/{P}v (p{LDH}/p{LDH}) {RDT} over a two-year period (2022 and 2023) and confirmed by real-time quantitative polymerase chain reaction. {T}he sensitivity and specificity for the detection of {P}. falciparum were 88.2% and 100%, respectively. {F}or {P}. vivax, the sensitivity was 86.7% and the specificity was 100%. {R}e-training and closer supervision of the technicians between 2022 and 2023 have led to an increased sensitivity to detect {P}. falciparum (69.8% in 2022 versus 88.2% in 2023; p < 0.01). {T}he receiver operating characteristic curve analysis highlighted a better performance in the diagnosis of {P}. falciparum with p{LDH}-based {RDT}s compared with previous {HRP}2-based {RDT}s. {I}n {D}jibouti, where pfhrp2-deleted strains are rapidly gaining ground, {LDH}-based {RDT}s seem to be more suitable for diagnosing {P}. falciparum than {HRP}2-based {RDT}s. {A}wareness-raising and training for technical staff have also been beneficial.},
  keywords = {diagnosis ; diagnostic performance ; {D}jibouti ; histidine-rich protein ; lactate dehydrogenase ; {P}lasmodium falciparum ; {P}lasmodium vivax ; rapid diagnostic test ; {DJIBOUTI}},
  booktitle = {},
  journal = {{D}iagnostics},
  volume = {14},
  numero = {3},
  pages = {262 [12 ]},
  year = {2024},
  DOI = {10.3390/diagnostics14030262},
  URL = {https://www.documentation.ird.fr/hor/fdi:010089539},
}