@article{fdi:010089488,
  title = {{D}espite structural identity, ace-1 heterogenous duplication resistance alleles are quite diverse in {A}nopheles mosquitoes},
  author = {{C}laret, {J}. {L}. and {D}i-{L}iegro, {M}. and {N}amias, {A}. and {A}ssogba, {B}. and {M}akoundou, {P}. and {K}offi, {A}. and {P}ennetier, {C}{\'e}dric and {W}eill, {M}. and {M}ilesi, {P}. and {L}abbe, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}nopheles gambiae s.l. has been the target of intense insecticide treatment since the mid-20th century to try and control malaria. {A} substitution in the ace-1 locus has been rapidly selected for, allowing resistance to organophosphate and carbamate insecticides. {S}ince then, two types of duplication of the ace-1 locus have been found in {A}n. gambiae s.l. populations: homogeneous duplications that are composed of several resistance copies, or heterogeneous duplications that contain both resistance and susceptible copies. {T}he substitution induces a trade-off between resistance in the presence of insecticides and disadvantages in their absence: the heterogeneous duplications allow the fixation of the intermediate heterozygote phenotype. {S}o far, a single heterogeneous duplication has been described in {A}n. gambiae s.l. populations (in contrast with the multiple duplicated alleles found in {C}ulex pipiens mosquitoes). {W}e used a new approach, combining long and short-read sequencing with {S}anger sequencing to precisely identify and describe at least nine different heterogeneous duplications, in two populations of {A}n. gambiae s.l. {W}e show that these alleles share the same structure as the previously identified heterogeneous and homogeneous duplications, namely 203-kb tandem amplifications with conserved breakpoints. {O}ur study sheds new light on the origin and maintenance of these alleles in {A}n. gambiae s.l. populations, and their role in mosquito adaptation.},
  keywords = {},
  booktitle = {},
  journal = {{H}eredity},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[13 p.]},
  ISSN = {0018-067{X}},
  year = {2024},
  DOI = {10.1038/s41437-024-00670-9},
  URL = {https://www.documentation.ird.fr/hor/fdi:010089488},
}