Body mass index and peripheral arterial disease, a 'U-shaped' relationship in elderly African population - the EPIDEMCA study Desormais I. auteur aut IRD Aboyans V. auteur aut IRD Guerchet Maëlenn auteur aut IRD Ndamba-Bandzouzi B. auteur aut IRD Mbelesso P. auteur aut IRD Magne J. auteur aut IRD Jesus P. auteur aut IRD Marin B. auteur aut IRD Lacroix P. auteur aut IRD Preux P.M. auteur aut IRD text journalArticle anglais text/pdf born digital access Background: There is no study available concerning specifically the role of underweight in PAD prevalence. Patients and methods: Individuals ? 65 years living in urban and rural areas of two countries in Central Africa (Central African Republic and the Republic of Congo) were invited. Demographic, clinical and biological data were collected, and ankle-brachial index measured. BMI was calculated as weight/height2 and participants were categorized according to the World Health Organization as with underweight (< 18.5 kg/m2), normal weight (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2), and obese (? 30 kg/m2). Results: Among the 1815 participants (age 73.0 years, 61.8 % females), the prevalence of underweight was 34.1 %, higher in subjects with PAD than in PAD free subjects (37.1 % vs. 33.5 %, p = 0.0333). The overall prevalence of PAD was 14.3 %. Underweight and obesity were still significantly associated with PAD after adjustment to all potential confounding factors (OR: 2.09, p = 0.0009 respectively OR: 1.90, p = 0.0336) while overweight was no more significantly associated with PAD after multivariate analysis. Conclusions: While obesity is a well-known PAD associated marker, low BMI provides novel independent and incremental information on African subject's susceptibility to present PAD, suggesting a "U-shaped" relationship between BMI and PAD in this population. specialized CENTRAFRIQUE CONGO 050EPID Vasa 49 1 50-56 2020 0301-1526 https://www.documentation.ird.fr/hor/fdi:010089032 10.1024/0301-1526/a000825 0301-1526 [F B010089032] https://www.documentation.ird.fr/hor/fdi:010089032 https://www.documentation.ird.fr/intranet/publi/2024-11/010089032.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2023-12-11 2025-02-24 fdi:010089032 fre