@article{fdi:010089028,
title = {{D}oes parity matter in women's risk of dementia ? : a {COSMIC} collaboration cohort study},
author = {{B}ae, {J}. {B}. and {L}ipnicki, {D}.{M}. and {H}an, {J}. {W}. and {S}achdev, {P}.{S}. and {K}im, {T}.{H}. and {K}wak, {K}.{P}. and {K}im, {B}. . and {K}im, {S}.{G}. and {K}im, {J}.{L}. and {M}oon, {S}.{W}. and {P}ark, {J}.{H}. and {R}yu, {S}..{H}. and {Y}oun, {J}.{C}. and {L}ee, {D}.{Y}. and {L}ee, {D}.{W} and {L}ee, {S}.{B}. and {L}ee, {J}.{J}. and {J}hoo, {J}.{H}. and {L}libre-{R}odriguez, {J}.{J}. and {L}libre-{G}uerra, {J}.{J}. and {V}alhuerdi-{C}epero, {A}.{J}. and {R}itchie, {K}. and {A}ncelin, {M}.{L}. and {C}arriere, {I}. and {S}koog, {I}. and {N}ajar, {J}. and {S}terner, {T}.{R}. and {S}carmeas, {N}. and {Y}annakoulia, {M}. and {D}ardiotis, {E}. and {M}eguro, {K}. and {K}asai, {M}. and {N}akamura, {K}. and {R}iedel-{H}eller, {S}. and {R}oehr, {S}. and {P}abst, {A}. and {V}an {B}oxtel, {M}. and {K}{\¨o}hler, {S}. and {D}ing, {D}. and {Z}hao, {Q}. and {L}iang, {X}. and {S}cazufca, {M}. and {L}obo, {A}. and {D}e-la-{C}ámara, {C}. and {L}obo, {E}. and {K}im, {K}.{W}. and {S}achdev, {P}.{S}. and {L}ipnicki, {D}.{M}. and {M}akkar, {S}.{R}. and {C}rawford, {J}.{D}. and {T}halamuthu, {A}. and {K}ochan, {N}.{A}. and {L}eung, {Y}. and {L}o, {J}.{W}. and {T}urana, {Y}. and {C}astro-{C}osta, {E}. and {L}arijani, {B}. and {N}abipour, {I}. and {R}ockwood, {K}. and {S}hifu, {X}. and {L}ipton, {R}.{B}. and {K}atz, {M}.{J}. and {P}reux, {P}.{M}. and {G}uerchet, {M}a{\¨e}lenn and {L}am, {L}. and {S}koog, {I}. and {N}inimiya, {T}. and {W}alker, {R}. and {H}endrie, {H}. and {G}uaita, {A}. and {C}hen, {L}.{K}. and {S}hahar, {S}. and {D}ominguez, {J}. and {K}rishna, {M}. and {G}anguli, {M}. and {A}nstey, {K}.{J}. and {C}rowe, {M}. and {H}aan, {M}.{N}. and {K}umagai, {S}. and {N}g, {T}.{P}. and {B}rodaty, {H}. and {M}eguro, {K}. and {M}ayeux, {R}. and {S}chupf, {N}. and {S}achdev, {P}. and {G}anguli, {M}. and {P}etersen, {R}. and {L}ipton, {R}. and {L}owe, {E}.{S}. and {R}itchie, {K}. and {K}im, {K}.{W}. and {J}orm, {L}. and {B}rodaty, {H}.},
editor = {},
language = {{ENG}},
abstract = {{B}ackground {D}ementia shows sex difference in its epidemiology. {C}hildbirth, a distinctive experience of women, is associated with the risk for various diseases. {H}owever, its association with the risk of dementia in women has rarely been studied. {M}ethods {W}e harmonized and pooled baseline data from 11 population-based cohorts from 11 countries over 3 continents, including 14,792 women aged 60 years or older. {W}e investigated the association between parity and the risk of dementia using logistic regression models that adjusted for age, educational level, hypertension, diabetes mellitus, and cohort, with additional analyses by region and dementia subtype. {R}esults {A}cross all cohorts, grand multiparous (5 or more childbirths) women had a 47% greater risk of dementia than primiparous (1 childbirth) women (odds ratio [{OR}] = 1.47, 95% confidence interval [{CI}] = 1.10-1.94), while nulliparous (no childbirth) women and women with 2 to 4 childbirths showed a comparable dementia risk to primiparous women. {H}owever, there were differences associated with region and dementia subtype. {C}ompared to women with 1 to 4 childbirths, grand multiparous women showed a higher risk of dementia in {E}urope ({OR} = 2.99, 95% {CI} = 1.38-6.47) and {L}atin {A}merica ({OR} = 1.49, 95% {CI} = 1.04-2.12), while nulliparous women showed a higher dementia risk in {A}sia ({OR} = 2.15, 95% {CI} = 1.33-3.47). {G}rand multiparity was associated with 6.9-fold higher risk of vascular dementia in {E}urope ({OR} = 6.86, 95% {CI} = 1.81-26.08), whereas nulliparity was associated with a higher risk of {A}lzheimer disease ({OR} = 1.91, 95% {CI} 1.07-3.39) and non-{A}lzheimer non-vascular dementia ({OR} = 3.47, 95% {CI} = 1.44-8.35) in {A}sia. {C}onclusion {P}arity is associated with women's risk of dementia, though this is not uniform across regions and dementia subtypes.},
keywords = {{CUBA} ; {FRANCE} ; {SUEDE} ; {GRECE} ; {COREE} {DU} {SUD} ; {JAPON} ; {ALLEMAGNE} ; {ESPAGNE} ; {PAYS} {BAS} ; {CHINE} ; {BRESIL}},
booktitle = {},
journal = {{BMC} {M}edicine},
volume = {18},
numero = {1},
pages = {210 [11 ]},
ISSN = {1741-7015},
year = {2020},
DOI = {10.1186/s12916-020-01671-1},
URL = {https://www.documentation.ird.fr/hor/fdi:010089028},
}