@article{fdi:010089018,
  title = {{T}he relationship between alcohol use and dementia in adults aged more than 60 years : a combined analysis of prospective, individual-participant data from 15 international studies},
  author = {{M}ewton, {L}. and {V}isontay, {R}. and {H}oy, {N}. and {L}ipnicki, {D}. and {S}underland, {M}. and {L}ipton, {R}.{B}. and {G}uerchet, {M}a{\¨e}lenn and {R}itchie, {K}. and {N}ajar, {J}. and {S}carmeas, {N}. and {K}im, {K}.{W}. and {R}iedel {H}eller, {S}. and {V}an {B}oxtel, {M}. and {J}acobsen, {E}. and {B}rodaty, {H}. and {A}nstey, {K}.{J}. and {H}aan, {M}. and {S}cazufca, {M}. and {L}obo, {E}. and {S}achdev, {P}.{S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}im : {T}o synthesize international findings on the alcohol-dementia relationship, including representation from low and middle income countries. {M}ethods : {I}ndividual participant data meta analysis of 15 prospective epidemiological cohort studies from countries situated in six continents. {C}ox regression investigated the dementia risk associated with alcohol use in older adults aged over 60 years. {A}dditional analyses assessed the alcohol-dementia relationship in the sample stratified by sex and by continent. {P}articipants included 24 478 community dwelling individuals without a history of dementia at baseline and at least one follow up dementia assessment. {T}he main outcome measure was all cause dementia as determined by clinical interview.{R}esults : {A}t baseline, the mean age across studies was 71.8 (standard deviation = 7.5, range = 60-102 years), 14 260 (58.3%) were female and 13 269 (54.2%) were current drinkers. {D}uring 151 636 person years of follow up, there were 2124 incident cases of dementia (14.0 per 1000 person years). {W}hen compared with abstainers, the risk for dementia was lower in occasional [hazard ratio ({HR}) = 0.78; 95% confidence interval ({CI}) = 0.68-0.89], light-moderate ({HR} = 0.78; 95% {CI} = 0.70-0.87) and moderate-heavy drinkers ({HR} = 0.62; 95% {CI} = 0.51-0.77). {T}here was no evidence of differences between life time abstainers and former drinkers in terms of dementia risk ({HR} = 0.98; 95% {CI} = 0.81-1.18). {I}n dose-response analyses, moderate drinking up to 40 g/day was associated with a lower risk of dementia when compared with lifetime abstaining. {A}mong current drinkers, there was no consistent evidence for differences in terms of dementia risk. {R}esults were similar when the sample was stratified by sex. {W}hen analysed at the continent level, there was considerable heterogeneity in the alcohol-dementia relationship. {C}onclusions : {A}bstinence from alcohol appears to be associated with an increased risk for all cause dementia. {A}mong current drinkers, there appears to be no consistent evidence to suggest that the amount of alcohol consumed in later life is associated with dementia risk.},
  keywords = {{ETATS} {UNIS} ; {FRANCE} ; {ESPAGNE} ; {SUEDE} ; {GRECE} ; {ALLEMAGNE} ; {PAYS} {BAS} ; {COREE} {DU} {SUD} ; {AUSTRALIE} ; {BRESIL} ; {CONGO}},
  booktitle = {},
  journal = {{A}ddiction},
  volume = {118},
  numero = {3},
  pages = {412--424},
  ISSN = {0965-2140},
  year = {2022},
  DOI = {10.1111/add.16035},
  URL = {https://www.documentation.ird.fr/hor/fdi:010089018},
}