@article{fdi:010088933,
  title = {{F}unctional alterations and predictive capacity of gut microbiome in type 2 diabetes},
  author = {{D}ash, {N}. {R}. and {A}l {B}ataineh, {M}. {T}. and {A}lili, {R}. and {A}l {S}afar, {H}. and {A}lkhayyal, {N}. and {P}rifti, {E}di and {Z}ucker, {J}ean-{D}aniel and {B}elda, {E}. and {C}l{\'e}ment, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he gut microbiome plays a significant role in the development of {T}ype 2 {D}iabetes {M}ellitus ({T}2{DM}), but the functional mechanisms behind this association merit deeper investigation. {H}ere, we used the nanopore sequencing technology for metagenomic analyses to compare the gut microbiome of individuals with {T}2{DM} from the {U}nited {A}rab {E}mirates (n = 40) with that of control (n = 44). {DMM} enterotyping of the cohort resulted concordantly with previous results, in three dominant groups {B}acteroides ({K}1), {F}irmicutes ({K}2), and {P}revotella ({K}3) lineages. {T}he diversity analysis revealed a high level of diversity in the {F}irmicutes group ({K}2) both in terms of species richness and evenness ({W}ilcoxon rank-sum test, p value < 0.05 vs. {K}1 and {K}3 groups), consistent with the {R}uminococcus enterotype described in {W}estern populations. {A}dditionally, functional enrichment analyses of {KEGG} modules showed significant differences in abundance between individuals with {T}2{DM} and controls ({FDR} < 0.05). {T}hese differences include modules associated with the degradation of amino acids, such as arginine, the degradation of urea as well as those associated with homoacetogenesis. {P}rediction analysis with the {P}redomics approach suggested potential biomarkers for {T}2{DM}, including a balance between a depletion of {E}nterococcus faecium and {B}lautia lineages with an enrichment of {A}bsiella spp or {E}ubacterium limosum in {T}2{DM} individuals, highlighting the potential of metagenomic analysis in predicting predisposition to diabetic cardiomyopathy in {T}2{DM} patients.},
  keywords = {{EMIRATS} {ARABES} {UNIS}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {13},
  numero = {1},
  pages = {22386 [12 p.]},
  ISSN = {2045-2322},
  year = {2023},
  DOI = {10.1038/s41598-023-49679-w},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088933},
}