@article{fdi:010088917,
  title = {{I}ncreasing the uptake of {I}ntermittent {P}reventive {T}reatment of malaria in pregnancy using {S}ulfadoxine-{P}yrimethamine ({IPT}p-{SP}) through seasonal malaria chemoprevention channel delivery : protocol of a multicenter cluster randomized implementation trial in {M}ali and {B}urkina {F}aso},
  author = {{K}oita, {K}. and {B}ognini, {J}. {D}. and {A}gboraw, {E}. and {D}embele, {M}. and {Y}abr{\`e}, {S}. and {B}ihoun, {B}. and {C}oulibaly, {O}. and {N}iangaly, {H}. and {N}'{T}akp{\'e}, {J}. {B}. and {L}esosky, {M}. and {S}caramuzzi, {D}. and {W}orrall, {E}. and {H}ill, {J}. and {B}riand, {V}al{\'e}rie and {T}into, {H}. and {K}ayentao, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {T}he uptake of {I}ntermittent {P}reventive {T}reatment of malaria in pregnancy using {S}ulfadoxine-{P}yrimethamine ({IPT}p-{SP}) remains unacceptably low, with more than two-thirds of pregnant women in sub-{S}aharan {A}frica still not accessing the three or more doses recommended by the {W}orld {H}ealth {O}rganisation ({WHO}). {I}n contrast, the coverage of {S}easonal {M}alaria {C}hemoprevention ({SMC}), a more recent strategy recommended by the {WHO} for malaria prevention in children under five years living in {S}ahelian countries with seasonal transmission, including {M}ali and {B}urkina-{F}aso, is high (up to 90%). {W}e hypothesized that {IPT}p-{SP} delivery to pregnant women through {SMC} alongside antenatal care ({ANC}) will increase {IPT}p-{SP} coverage, boost {ANC} attendance, and increase public health impact. {T}his protocol describes the approach to assess acceptability, feasibility, effectiveness, and cost-effectiveness of the integrated strategy.{M}ethods and analysis {T}his is a multicentre, cluster-randomized, implementation trial of {IPT}p-{SP} delivery through {ANC} + {SMC} vs {ANC} alone in 40 health facilities and their catchment populations (20 clusters per arm). {T}he intervention will consist of monthly administration of {IPT}p-{SP} through four monthly rounds of {SMC} during the malaria transmission season ({J}uly to {O}ctober), for two consecutive years. {E}ffectiveness of the strategy to increase coverage of three or more doses of {IPT}p-{SP} ({IPT}p3 +) will be assessed using household surveys and {ANC} exit interviews. {S}tatistical analysis of {IPT}3 + and four or more {ANC} uptake will use a generalized linear mixed model. {F}easibility and acceptability will be assessed through in-depth interviews and focus group discussions with health workers, pregnant women, and women with a child < 12 months.{D}iscussion {T}his multicentre cluster randomized implementation trial powered to detect a 45% and 22% increase in {IPT}p-{SP}3 + uptake in {M}ali and {B}urkina-{F}aso, respectively, will generate evidence on the feasibility, acceptability, effectiveness, and cost-effectiveness of {IPT}p-{SP} delivered through the {ANC} + {SMC} channel. {T}he intervention is designed to facilitate scalability and translation into policy by leveraging existing resources, while strengthening local capacities in research, health, and community institutions. {F}indings will inform the local national malaria control policies.},
  keywords = {{M}alaria ; {P}regnant women ; {W}omen with a child less than 12 months of age ; {T}ropical medicine ; {I}nfectious diseases ; {M}aternal and child health ; {E}pidemiology ; {MALI} ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{BMC} {P}ublic {H}ealth},
  volume = {24},
  numero = {1},
  pages = {43 [13 ]},
  year = {2024},
  DOI = {10.1186/s12889-023-17529-z},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088917},
}