@article{fdi:010088900,
  title = {{O}ne hundred malaria attacks since birth : a longitudinal study of {A}frican children and young adults exposed to high malaria transmission},
  author = {{T}rape, {J}ean-{F}ran{\c{c}}ois and {D}iagne, {N}afissatou and {D}iene-{S}arr, {F}. and {F}aye, {J}. and {D}ieye-{B}a, {F}. and {B}ass{\`e}ne, {H}. and {B}adiane, {A}. and {B}ouganali, {C}harles and {T}all, {A}. and {N}diaye, {R}. and {D}oucour{\'e}, {S}ouleymane and {W}otodjo, {A}. {N}. and {V}igan-{W}omas, {I}. and {G}uillotte-{B}lisnick, {M}. and {T}alla, {C}. and {N}iang, {M}. and {T}our{\'e}-{B}ald{\'e}, {A}. and {P}erraut, {R}. and {R}oussilhon, {C}. and {D}ruilhe, {P}. and {R}ogier, {C}. and {M}ercereau-{P}uijalon, {O}. and {L}oucoubar, {C}. and {S}okhna, {C}heikh},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {D}espite significant progress in malaria control over the past twenty years, malaria remains a leading cause of child morbidity and mortality in {T}ropical {A}frica. {A}s most patients do not consult any health facility much uncertainty persists about the true burden of the disease and the range of individual differences in susceptibility to malaria.{M}ethods {O}ver a 25-years period, from 1990 to 2015, the inhabitants of {D}ielmo village, {S}enegal, an area of intense malaria transmission, have been monitored daily for their presence in the village and the occurrence of diseases. {I}n case of fever thick blood films were systematically examined through microscopy for malaria parasites and patients received prompt diagnosis and treatment. {F}indings {W}e analysed data collected in 111 children and young adults monitored for at least 10 years (mean 17.3 years, maximum 25 years) enrolled either at birth (95 persons) or during the two first years of life. {A} total of 11,599 episodes of fever were documented, including 5268 malaria attacks. {T}he maximum number of malaria attacks in a single person was 112. {T}hree other persons suffered one hundred or more malaria attacks during follow-up. {T}he minimum number of malaria attacks in a single person was 11. {T}he mean numbers of malaria attacks in children reaching their 4th, 7th, and 10th birthdays were 23.0, 37.7, and 43.6 attacks since birth, respectively. {S}ixteen children (14.4%) suffered ten or more malaria attacks each year at ages 1-3 years, and six children (5.4%) each year at age 4-6 years. {I}nterpretation {L}ong-term close monitoring shows that in highly endemic areas the malaria burden is higher than expected. {S}usceptibility to the disease may vary up to 10-fold, and for most children childhood is an endless history of malaria fever episodes. {N}o other parasitic, bacterial or viral infection in human populations has such an impact on health. 2024;67: {P}ublished https://doi.org/10. 1016/j.eclinm.2023. 102379},
  keywords = {{M}alaria ; {A}frica ; {M}orbidity ; {E}pidemiology ; {I}mmunology ; {C}ohort study ; {L}ongitudinal study ; {P}lasmodium falciparum ; {P}lasmodium malariae ; {P}lasmodium ovale ; {C}hildren ; {I}nfants ; {S}enegal ; {SENEGAL}},
  booktitle = {},
  journal = {{E}clinicalmedicine},
  volume = {67},
  numero = {},
  pages = {102379 [11 ]},
  year = {2024},
  DOI = {10.1016/j.eclinm.2023.102379},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088900},
}