@article{fdi:010088897,
  title = {{M}osquito ageing modulates the development, virulence and transmission potential of pathogens},
  author = {{S}om{\'e}, {B}. {M}. and {G}uissou, {E}. and {D}a, {D}. {F}. and {R}ichard, {Q}. and {C}hoisy, {M}. and {Y}ameogo, {K}. {B}. and {H}ien, {D}. {F}. and {Y}erbanga, {R}. {S}. and {O}uedraogo, {G}. {A}. and {D}abir{\'e}, {K}. {R}. and {D}jidjou-{D}emasse, {R}ams{\`e}s and {C}ohuet, {A}nna and {L}ef{\`e}vre, {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}ost age variation is a striking source of heterogeneity that can shape the evolution and transmission dynamic of pathogens. {C}ompared with vertebrate systems, our understanding of the impact of host age on invertebrate-pathogen interactions remains limited. {W}e examined the influence of mosquito age on key life-history traits driving human malaria transmission. {F}emales of {A}nopheles coluzzii, a major malaria vector, belonging to three age classes (4-, 8- and 12-day-old), were experimentally infected with {P}lasmodium falciparum field isolates. {O}ur findings revealed reduced competence in 12-day-old mosquitoes, characterized by lower oocyst/sporozoite rates and intensities compared with younger mosquitoes. {D}espite shorter median longevities in older age classes, infected 12-day-old mosquitoes exhibited improved survival, suggesting that the infection might act as a fountain of youth for older mosquitoes specifically. {T}he timing of sporozoite appearance in the salivary glands remained consistent across mosquito age classes, with an extrinsic incubation period of approximately 13 days. {I}ntegrating these results into an epidemiological model revealed a lower vectorial capacity for older mosquitoes compared with younger ones, albeit still substantial owing to extended longevity in the presence of infection. {C}onsidering age heterogeneity provides valuable insights for ecological and epidemiological studies, informing targeted control strategies to mitigate pathogen transmission.},
  keywords = {ageing ; pathogen transmission ; malaria ; mosquito ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{P}roceedings of the {R}oyal {S}ociety {B} : {B}iological {S}ciences},
  volume = {291},
  numero = {2014},
  pages = {20232097 [12 p.]},
  ISSN = {0962-8452},
  year = {2024},
  DOI = {10.1098/rspb.2023.2097},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088897},
}