@article{fdi:010088891,
  title = {{V}iral components trafficking with(in) extracellular vesicles},
  author = {{R}ey-{C}adilhac, {F}. and {R}achenne, {F}. and {M}iss{\'e}, {D}oroth{\'e}e and {P}ompon, {J}ulien},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he global public health burden exerted by viruses partially stems from viruses' ability to subdue host cells into creating an environment that promotes their multiplication (i.e., pro-viral). {I}t has been discovered that viruses alter cell physiology by transferring viral material through extracellular vesicles ({EV}s), which serve as vehicles for intercellular communication. {H}ere, we aim to provide a conceptual framework of all possible {EV}-virus associations and their resulting functions in infection output. {F}irst, we describe the different viral materials potentially associated with {EV}s by reporting that {EV}s can harbor entire virions, viral proteins and viral nucleic acids. {W}e also delineate the different mechanisms underlying the internalization of these viral components into {EV}s. {S}econd, we describe the potential fate of {EV}-associated viral material cargo by detailing how {EV} can circulate and target a naive cell once secreted. {F}inally, we itemize the different pro-viral strategies resulting from {EV} associations as the {T}rojan horse strategy, an alternative mode of viral transmission, an expansion of viral cellular tropism, a pre-emptive alteration of host cell physiology and an immunity decoy. {W}ith this conceptual overview, we aim to stimulate research on {EV}-virus interactions.},
  keywords = {extracellular vesicles ; viruses ; infection ; exosomes ; microvesicles ; cell-cell communication},
  booktitle = {},
  journal = {{V}iruses},
  volume = {15},
  numero = {12},
  pages = {2333 [17 p.]},
  year = {2023},
  DOI = {10.3390/v15122333},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088891},
}